Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes
about
Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac diseasePossession of human leucocyte antigen DQ6 alleles and the rate of CD4 T-cell decline in human immunodeficiency virus-1 infectionMechanisms of autoimmune thyroid diseases: from genetics to epigeneticsTargeting the trimolecular complexRisk factors and primary prevention trials for type 1 diabetesImmunotherapy in autoimmune type 1 diabetesStructural Basis of Cytochrome c Presentation by IE kAlternate interactions define the binding of peptides to the MHC molecule IA(b).A Naturally Selected Dimorphism within the HLA-B44 Supertype Alters Class I Structure, Peptide Repertoire, and T Cell RecognitionExploration of the P6/P7 region of the peptide-binding site of the human class II major histocompatability complex protein HLA-DR1Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsyPredominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect.Molecular Interactions Governing Autoantigen Presentation in Type 1 DiabetesGenetics of type 1 diabetes mellitusAdditive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes riskGenetics of type 1 diabetes: what's next?Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity.Identification of T1D susceptibility genes within the MHC region by combining protein interaction networks and SNP genotyping dataPrediction of HLA-DQ8beta cell peptidome using a computational program and its relationship to autoreactive T cellsDifferences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation.Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register.Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetopeExtra-thymically induced regulatory T cells: do they have potential in disease prevention?HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac diseaseHLA-DP2 binding prediction by molecular dynamics simulations.Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptideStructure-based selection of small molecules to alter allele-specific MHC class II antigen presentationHLA-DRB1-DQB1 haplotypes confer susceptibility and resistance to multiple sclerosis in Sardinia.Treg vaccination with a strong-agonistic insulin mimetope.Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid diseaseHLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM.A pH-sensitive histidine residue as control element for ligand release from HLA-DR moleculesBinding interactions between peptides and proteins of the class II major histocompatibility complex.The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD miceCharacterization of HKE2: an ancient antigen encoded in the major histocompatibility complex.Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes.Differential binding of pyruvate dehydrogenase complex-E2 epitopes by DRB1*08:01 and DRB1*11:01 Is predicted by their structural motifs and correlates with disease risk.Molecular properties of HLA-DQ alleles conferring susceptibility to or protection from insulin-dependent diabetes mellitus: keys to the fate of islet beta-cells.Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humansT cell receptor recognition of self and foreign antigens in the induction of autoimmunity.
P2860
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P2860
Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Structure of a human insulin p ...... ceptibility to type 1 diabetes
@ast
Structure of a human insulin p ...... ceptibility to type 1 diabetes
@en
Structure of a human insulin p ...... ceptibility to type 1 diabetes
@nl
type
label
Structure of a human insulin p ...... ceptibility to type 1 diabetes
@ast
Structure of a human insulin p ...... ceptibility to type 1 diabetes
@en
Structure of a human insulin p ...... ceptibility to type 1 diabetes
@nl
prefLabel
Structure of a human insulin p ...... ceptibility to type 1 diabetes
@ast
Structure of a human insulin p ...... ceptibility to type 1 diabetes
@en
Structure of a human insulin p ...... ceptibility to type 1 diabetes
@nl
P2093
P2860
P3181
P356
P1433
P1476
Structure of a human insulin p ...... ceptibility to type 1 diabetes
@en
P2093
K W Wucherpfennig
P2860
P3181
P356
10.1038/88694
P407
P577
2001-06-01T00:00:00Z