Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
about
Comparative active-site mutation study of human and Caenorhabditis elegans thymidine kinase 1Kinetic properties of mutant deoxyguanosine kinase in a case of reversible hepatic mtDNA depletionStructural studies of thymidine kinases from Bacillus anthracis and Bacillus cereus provide insights into quaternary structure and conformational changes upon substrate bindingFunctional studies of active-site mutants from Drosophila melanogaster deoxyribonucleoside kinase. Investigations of the putative catalytic glutamate-arginine pair and of residues responsible for substrate specificityStructural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinaseStructure of a type II thymidine kinase with bound dTTPReaction of human UMP-CMP kinase with natural and analog substratesMitochondrial DNA depletion and dGK gene mutationsNucleotide promiscuity of 3-phosphoglycerate kinase is in focus: implications for the design of better anti-HIV analoguesThymidine kinase 1 regulatory fine-tuning through tetramer formationOverview of protein structural and functional folds.Non-homologous recombination of deoxyribonucleoside kinases from human and Drosophila melanogaster yields human-like enzymes with novel activities.Systematic exploration of active site mutations on human deoxycytidine kinase substrate specificityOxidative stress induced S-glutathionylation and proteolytic degradation of mitochondrial thymidine kinase 2The phylogenetic distribution and evolution of enzymes within the thymidine kinase 2-like gene family in metazoa.Mutagenesis of non-conserved active site residues improves the activity and narrows the specificity of human thymidine kinase 2Deoxyribonucleoside kinases in mitochondrial DNA depletion.Biological phosphorylation of an Unnatural Base Pair (UBP) using a Drosophila melanogaster deoxynucleoside kinase (DmdNK) mutant.Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Sequence analysis of a non-classified, non-occluded DNA virus that causes salivary gland hypertrophy of Musca domestica, MdSGHV.Molecular mechanisms of mitochondrial DNA depletion diseases caused by deficiencies in enzymes in purine and pyrimidine metabolism.Structural basis of the substrate preference towards CMP for a thymidylate synthase MilA involved in mildiomycin biosynthesis.Dementia with Lewy Bodies: Molecular Pathology in the Frontal Cortex in Typical and Rapidly Progressive Forms.Enzymatic regulation of cytosolic thymidine kinase 1 and mitochondrial thymidine kinase 2: a mini review.Chemical architecture and applications of nucleic acid derivatives containing 1,2,3-triazole functionalities synthesized via click chemistry.Selective Phosphorylation of South and North-Cytidine and Adenosine Methanocarba-Nucleosides by Human Nucleoside and Nucleotide Kinases Correlates with Their Growth Inhibitory Effects on Cultured Cells.A few amino acid substitutions can convert deoxyribonucleoside kinase specificity from pyrimidines to purines.Mosquito has a single multisubstrate deoxyribonucleoside kinase characterized by unique substrate specificity.Nonpolar nucleoside mimics as active substrates for human thymidine kinases.Enhanced toxicity of purine nucleoside analogs in cells expressing Drosophila melanogaster nucleoside kinase mutants.Structural basis for the changed substrate specificity of Drosophila melanogaster deoxyribonucleoside kinase mutant N64D.Structure of mammalian respiratory complex IArchitecture of mammalian respiratory complex I.Novel deoxynucleoside-phosphorylating enzymes in mycoplasmas: evidence for efficient utilization of deoxynucleosides.Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathy.Striking ability of adenosine-2'(3')-deoxy-3'(2')-triphosphates and related analogues to replace ATP as phosphate donor for all four human, and the Drosophila melanogaster, deoxyribonucleoside kinases.Hydrodynamic and spectroscopic studies of substrate binding to human recombinant deoxycytidine kinase.Active site mutants of Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.Ability of adenosine-2'(3')-deoxy-3'(2')-triphosphates and related analogues to replace ATP as phosphate donor for all human and Drosphila melanogaster deoxyribonucleoside kinases.Reversible tetramerization of human TK1 to the high catalytic efficient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration.
P2860
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P2860
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
@ast
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
@en
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
@nl
type
label
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
@ast
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
@en
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
@nl
prefLabel
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
@ast
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
@en
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
@nl
P2093
P356
P1476
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
@en
P2093
B Munch-Petersen
C Ljungcrantz
K Johansson
S Eriksson
S Ramaswamy
P2888
P304
P356
10.1038/89661
P407
P577
2001-07-01T00:00:00Z
P6179
1007545276