Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine
about
X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene clusterOligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesisThe catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshotsThe paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerusTwo sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerusCrystal structure of carbapenem synthase (CarC)Crystal structure of carbapenam synthetase (CarA)Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathwayConvergent biosynthetic pathways to β-lactam antibioticsCharacterization of LtsA from Rhodococcus erythropolis, an enzyme with glutamine amidotransferase activityOsmotically induced synthesis of the dipeptide N-acetylglutaminylglutamine amide is mediated by a new pathway conserved among bacteria.A comparison of the clavam biosynthetic gene clusters in Streptomyces antibioticus Tü1718 and Streptomyces clavuligerus.Dissecting the maturation steps of the lasso peptide microcin J25 in vitro.A conserved glutamate controls the commitment to acyl-adenylate formation in asparagine synthetaseThe enzymes of β-lactam biosynthesis.Characterization of FdmV as an amide synthetase for fredericamycin A biosynthesis in Streptomyces griseus ATCC 43944.ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid.Asparagine synthetase chemotherapy.Regulation and biosynthesis of carbapenem antibiotics in bacteria.The evolution of gene collectives: How natural selection drives chemical innovation.Low-molecular-weight post-translationally modified microcins.iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.Transposon mutagenesis of probiotic Lactobacillus casei identifies asnH, an asparagine synthetase gene involved in its immune-activating capacity.Biosynthesis of clavam metabolites.Origins of the β-lactam rings in natural products.Rate-limiting steps and role of active site Lys443 in the mechanism of carbapenam synthetase.A conserved lysine in beta-lactam synthetase assists ring cyclization: Implications for clavam and carbapenem biosynthesis.A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase.Identification and characterization of a NaCl-responsive genetic locus involved in survival during desiccation in Sinorhizobium meliloti.Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics.5S clavam biosynthesis is controlled by an atypical two-component regulatory system in Streptomyces clavuligerusORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity.Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights.
P2860
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P2860
Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Structure of beta-lactam synth ...... ibiotics instead of asparagine
@ast
Structure of beta-lactam synth ...... ibiotics instead of asparagine
@en
Structure of beta-lactam synth ...... ibiotics instead of asparagine
@nl
type
label
Structure of beta-lactam synth ...... ibiotics instead of asparagine
@ast
Structure of beta-lactam synth ...... ibiotics instead of asparagine
@en
Structure of beta-lactam synth ...... ibiotics instead of asparagine
@nl
prefLabel
Structure of beta-lactam synth ...... ibiotics instead of asparagine
@ast
Structure of beta-lactam synth ...... ibiotics instead of asparagine
@en
Structure of beta-lactam synth ...... ibiotics instead of asparagine
@nl
P2093
P356
P1476
Structure of beta-lactam synth ...... ibiotics instead of asparagine
@en
P2093
A C Rosenzweig
B O Bachmann
C A Townsend
M T Miller
P356
10.1038/90394
P577
2001-08-01T00:00:00Z