Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations
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Crystal structures of penicillin-binding protein 2 from penicillin-susceptible and -resistant strains of Neisseria gonorrhoeae reveal an unexpectedly subtle mechanism for antibiotic resistanceThe structural modifications induced by the M339F substitution in PBP2x from Streptococcus pneumoniae further decreases the susceptibility to beta-lactams of resistant strainsA PBP2x from a clinical isolate of Streptococcus pneumoniae exhibits an alternative mechanism for reduction of susceptibility to beta-lactam antibioticsCommon alterations in PBP1a from resistant Streptococcus pneumoniae decrease its reactivity toward beta-lactams: structural insightsUnusual Conformation of the SxN Motif in the Crystal Structure of Penicillin-Binding Protein A from Mycobacterium tuberculosisCrystal Structures of Penicillin-Binding Protein 3 from Pseudomonas aeruginosa: Comparison of Native and Antibiotic-Bound FormsX-ray structural studies of the entire extracellular region of the serine/threonine kinase PrkC from Staphylococcus aureusThe Role of the β5–α11 Loop in the Active-Site Dynamics of Acylated Penicillin-Binding Protein A from Mycobacterium tuberculosisHow allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological functionStructural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosisPenicillin-binding proteins and beta-lactam resistanceEvidence from artificial septal targeting and site-directed mutagenesis that residues in the extracytoplasmic β domain of DivIB mediate its interaction with the divisomal transpeptidase PBP 2BInsight into the Diversity of Penicillin-Binding Protein 2x Alleles and Mutations in Viridans Streptococci.The highly conserved serine threonine kinase StkP of Streptococcus pneumoniae contributes to penicillin susceptibility independently from genes encoding penicillin-binding proteins.Protein kinase B (PknB) of Mycobacterium tuberculosis is essential for growth of the pathogen in vitro as well as for survival within the host.New approaches towards the identification of antibiotic and vaccine targets in Streptococcus pneumoniae.New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria.The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localizationThe bacterial cell wall as a source of antibacterial targets.Genetic analysis of the cell division protein FtsI (PBP3): amino acid substitutions that impair septal localization of FtsI and recruitment of FtsN.FemABX peptidyl transferases: a link between branched-chain cell wall peptide formation and beta-lactam resistance in gram-positive cocci.A highly conserved interaction involving the middle residue of the SXN active-site motif is crucial for function of class B penicillin-binding proteins: mutational and computational analysis of PBP 2 from N. gonorrhoeaeMessenger functions of the bacterial cell wall-derived muropeptides.Molecular genetic methods in diagnosis and direct characterization of acute bacterial central nervous system infections.The StkP/PhpP signaling couple in Streptococcus pneumoniae: cellular organization and physiological characterizationEukaryote-like serine/threonine kinases and phosphatases in bacteria.Molecular mechanisms of β-lactam resistance in Streptococcus pneumoniae.Development of new drugs for an old target: the penicillin binding proteins.Crystallization and preliminary crystallographic analysis of the transpeptidase domain of penicillin-binding protein 2B from Streptococcus pneumoniae.Functional characterization of penicillin-binding protein 1b from Streptococcus pneumoniae.β-Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis.Comprehensive identification of single nucleotide polymorphisms associated with beta-lactam resistance within pneumococcal mosaic genes.Evolution of transmembrane protein kinases implicated in coordinating remodeling of gram-positive peptidoglycan: inside versus outside.Penicillin-binding protein 2x of Streptococcus pneumoniae: the mutation Ala707Asp within the C-terminal PASTA2 domain leads to destabilization.Emergence of meningococci with reduced susceptibility to third-generation cephalosporins.A large displacement of the SXN motif of Cys115-modified penicillin-binding protein 5 from Escherichia coli.A new mechanism to render clinical isolates of Escherichia coli non-susceptible to imipenem: substitutions in the PBP2 penicillin-binding domain.An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.Crystallization and initial X-ray diffraction study of the three PASTA domains of the Ser/Thr kinase Stk1 from the human pathogen Staphylococcus aureus.Interactions between late-acting proteins required for peptidoglycan synthesis during sporulation.
P2860
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P2860
Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Crystal structure of PBP2x fro ...... mework containing 83 mutations
@ast
Crystal structure of PBP2x fro ...... mework containing 83 mutations
@en
Crystal structure of PBP2x fro ...... mework containing 83 mutations
@nl
type
label
Crystal structure of PBP2x fro ...... mework containing 83 mutations
@ast
Crystal structure of PBP2x fro ...... mework containing 83 mutations
@en
Crystal structure of PBP2x fro ...... mework containing 83 mutations
@nl
prefLabel
Crystal structure of PBP2x fro ...... mework containing 83 mutations
@ast
Crystal structure of PBP2x fro ...... mework containing 83 mutations
@en
Crystal structure of PBP2x fro ...... mework containing 83 mutations
@nl
P2093
P2860
P356
P1476
Crystal structure of PBP2x fro ...... mework containing 83 mutations
@en
P2093
P2860
P304
45106-45112
P356
10.1074/JBC.M107608200
P407
P577
2001-09-11T00:00:00Z