Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor
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Solution Structure of Inhibitor-Free Human Metalloelastase (MMP-12) Indicates an Internal Conformational AdjustmentThe intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modelingPeptide-bond modification for metal coordination: peptides containing two hydroxamate groups.Apparent tradeoff of higher activity in MMP-12 for enhanced stability and flexibility in MMP-3.NMR and bioinformatics discovery of exosites that tune metalloelastase specificity for solubilized elastin and collagen triple helices.Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).Probing water-protein contacts in a MMP-12/CGS27023A complex by nuclear magnetic resonance spectroscopy.Expression of matrix metalloproteinase-12 in aortic dissectionStructural basis of the matrix metalloproteinases and their physiological inhibitors, the tissue inhibitors of metalloproteinases.Role for macrophage metalloelastase in glomerular basement membrane damage associated with alport syndromeExpression of MMP-2,TIMP-2 protein and the ratio of MMP-2/TIMP-2 in gallbladder carcinoma and their significanceClinical evaluation of a matrix metalloproteinase-12 cleaved fragment of titin as a cardiovascular serological biomarker.Antiangiogenic effect of somatostatin receptor subtype 2 on pancreatic cancer cell line: Inhibition of vascular endothelial growth factor and matrix metalloproteinase-2 expression in vitro.MMP-12 catalytic domain recognizes triple helical peptide models of collagen V with exosites and high activity.Development of novel Meju starter culture using plant extracts with reduced Bacillus cereus counts and enhanced functional properties.Molecular determinants of matrix metalloproteinase-12 covalent modification by a photoaffinity probe: insights into activity-based probe development and conformational variability of matrix metalloproteinases.Development of actinobacterial resources for functional cosmetics.Solvent water interactions within the active site of the membrane type I matrix metalloproteinase.The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors – characterization of hydroxamate-based matrix metalloproteinase-12 inhibitorsMacrophage metalloelastase (MME) as adjuvant for intra-tumoral injection of oncolytic adenovirus and its influence on metastases development
P2860
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P2860
Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Crystal structure of human mac ...... th a hydroxamic acid inhibitor
@ast
Crystal structure of human mac ...... th a hydroxamic acid inhibitor
@en
Crystal structure of human mac ...... th a hydroxamic acid inhibitor
@nl
type
label
Crystal structure of human mac ...... th a hydroxamic acid inhibitor
@ast
Crystal structure of human mac ...... th a hydroxamic acid inhibitor
@en
Crystal structure of human mac ...... th a hydroxamic acid inhibitor
@nl
prefLabel
Crystal structure of human mac ...... th a hydroxamic acid inhibitor
@ast
Crystal structure of human mac ...... th a hydroxamic acid inhibitor
@en
Crystal structure of human mac ...... th a hydroxamic acid inhibitor
@nl
P2093
P356
P1476
Crystal structure of human mac ...... th a hydroxamic acid inhibitor
@en
P2093
P304
P356
10.1006/JMBI.2001.4953
P407
P577
2001-09-28T00:00:00Z