Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase
about
Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylaseFunction and evolution of the serotonin-synthetic bas-1 gene and other aromatic amino acid decarboxylase genes in CaenorhabditisCrystal structure and functional analysis of Escherichia coli glutamate decarboxylaseGABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loopCrystal Structure and Substrate Specificity of Drosophila 3,4-Dihydroxyphenylalanine DecarboxylaseOpen conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylasesIdentifying key residues of sphinganine-1-phosphate lyase for function in vivo and in vitro.Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitorsLocal changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stabilityStructural and functional analysis of cysteine residues in human glutamate decarboxylase 65 (GAD65) and GAD67.Internal proton transfer in the external pyridoxal 5'-phosphate Schiff base in dopa decarboxylase.Region-specific protein abundance changes in the brain of MPTP-induced Parkinson's disease mouse modelA dopa decarboxylase modulating the immune response of scallop Chlamys farreriMutational analysis of substrate interactions with the active site of dialkylglycine decarboxylaseDiscovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine.Kinetic isotope effects of L-Dopa decarboxylase.Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancersIntersubunit signaling in glutamate-1-semialdehyde-aminomutase.Biogenic amines and polyamines: similar biochemistry for different physiological missions and biomedical applications.Purification, crystallization and preliminary X-ray analysis of human histidine decarboxylase.A comprehensive view of polyamine and histamine metabolism to the light of new technologies."Zipped Synthesis" by Cross-Metathesis Provides a Cystathionine β-Synthase Inhibitor that Attenuates Cellular H2S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model.Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding.Computation of kinetic isotope effects for enzymatic reactions.Molecular dynamics simulations of the intramolecular proton transfer and carbanion stabilization in the pyridoxal 5'-phosphate dependent enzymes L-dopa decarboxylase and alanine racemase.Structural Basis of the Substrate Specificity and Enzyme Catalysis of a Papaver somniferum Tyrosine Decarboxylase.Biochemical and computational approaches to improve the clinical treatment of dopa decarboxylase-related diseases: an overviewCatalysis in Enzymatic Decarboxylations: Comparison of Selected Cofactor-dependent and Cofactor-independent Examples.ProteinsPlus: a web portal for structure analysis of macromolecules.Mitochondrial permeability transition pore: a promising target for the treatment of Parkinson's disease.In silico target fishing for the potential targets and molecular mechanisms of baicalein as an antiparkinsonian agent: discovery of the protective effects on NMDA receptor-mediated neurotoxicity.Chemogenomics of pyridoxal 5'-phosphate dependent enzymes.Interaction of human Dopa decarboxylase with L-Dopa: spectroscopic and kinetic studies as a function of pH.Mapping of catalytically important residues in the rat L-histidine decarboxylase enzyme using bioinformatic and site-directed mutagenesis approaches.Kinetic analyses guide the therapeutic decision in a novel form of moderate aromatic Acid decarboxylase deficiencyEvolutionarily conserved regions and hydrophobic contacts at the superfamily level: The case of the fold-type I, pyridoxal-5'-phosphate-dependent enzymes.Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia.Mutation of tyrosine 332 to phenylalanine converts dopa decarboxylase into a decarboxylation-dependent oxidative deaminase.The critical structural role of a highly conserved histidine residue in group II amino acid decarboxylases.Cross talk between the intrarenal dopaminergic and cyclooxygenase-2 systems.
P2860
Q24339546-D1D21A8F-8C1F-43B5-B2DC-4ED27C6C1FCAQ24803204-ABCFAC63-28E9-4E2B-BB06-3C739E2337BDQ27641829-1032E711-8BD1-4165-81DD-D4B9A7F53C6CQ27644229-CBBBEC9E-632F-4905-A2C1-3F9E37509843Q27659151-870DAA9B-5AEE-44A3-99A4-C6C50B1674FDQ27675992-231A62DF-9D68-4773-9F72-A639EE155E08Q27935775-3C6E6CAD-B715-4390-A343-9F10DA540646Q28481220-C3337C96-CD21-4B50-B6BF-A883987A4236Q28584255-B79B98EA-F9B0-4D95-897F-EA7AB9060185Q31160750-07D11604-E3A6-48C7-A606-0FD0CAB045EEQ33685234-1090CB15-8F23-4443-B4AF-A9530E077CD7Q33810589-034B5739-FAB5-44EF-81D9-BD62A0892AD6Q33886778-1FFB3D48-81A7-4454-A9A5-74DE92393AC7Q34366533-B40A499B-644C-4FDF-85D3-C4FDF0E0DA62Q34440742-E1C5F47E-9853-4427-87AB-C5320DFC6A2EQ34764634-26E0817F-86AE-431E-8207-49B4BB11F287Q34945291-AEB320BC-AACA-40A4-A78B-9FEE9263670FQ35025109-D720D35E-07C7-4CE8-8ED7-5C2B41639162Q35086731-D70AE95B-2117-4D7C-875E-5DA74944B94FQ36019229-56894AC3-AC72-4243-B641-E8622BDCE075Q36346498-6F576D7C-49D5-4248-A906-D717A5F6ED2AQ36850630-69793E3E-EEEC-4279-A602-AD26C06CE020Q36996107-FCADE404-77CE-4F1E-BEAA-20600BF0872DQ37112024-E3CEE874-2A4A-4104-8E2F-E624EEA56F6CQ37191277-2A6B1E18-AF5A-4C77-83D4-8BD750B6EA54Q37632979-8138D310-0AE1-425C-A5C2-280A6A5A819BQ38069579-45702FAD-BC36-49D2-8B44-1E6C67F815AEQ38126497-37A33453-EB46-4CC7-86DF-CAE8523A9B02Q38687678-A0AB51D1-5959-44E2-A01E-AB1379FFE927Q38716156-E49F2F4F-5AA8-4847-96C8-DCD8AF624CD3Q39185205-4C8CF785-1F48-4B26-BBE8-CF211671B144Q39674260-62E6BEB6-8F08-49CE-8E83-745A17C64A2FQ42147273-81CAC469-704C-477D-AE18-E78F0B559239Q42152892-763F13E0-DD26-4103-8B82-2BE54C83D8BFQ42254457-6955481B-A0F6-4C7A-8F68-DFCA3F08AD43Q42638678-955E19D6-6629-4378-8592-9AD507C2A465Q42651682-3E7CDECA-6A25-4F5A-B19D-E53C04E22A38Q44064094-A42A85C6-4124-485D-89E7-2E27755A1FAFQ44641472-2C8E0793-007C-4BC4-A933-F4AB992C39E7Q45197555-36CA5FD0-FF69-4746-ADAB-532027FDA6E3
P2860
Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Structural insight into Parkin ...... g-inhibited DOPA decarboxylase
@ast
Structural insight into Parkin ...... g-inhibited DOPA decarboxylase
@en
Structural insight into Parkin ...... g-inhibited DOPA decarboxylase
@nl
type
label
Structural insight into Parkin ...... g-inhibited DOPA decarboxylase
@ast
Structural insight into Parkin ...... g-inhibited DOPA decarboxylase
@en
Structural insight into Parkin ...... g-inhibited DOPA decarboxylase
@nl
prefLabel
Structural insight into Parkin ...... g-inhibited DOPA decarboxylase
@ast
Structural insight into Parkin ...... g-inhibited DOPA decarboxylase
@en
Structural insight into Parkin ...... g-inhibited DOPA decarboxylase
@nl
P2093
P356
P1476
Structural insight into Parkin ...... g-inhibited DOPA decarboxylase
@en
P2093
C Borri-Voltattorni
J N Jansonius
P Burkhard
P Dominici
V N Malashkevich
P356
10.1038/NSB1101-963
P577
2001-11-01T00:00:00Z