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Structure-guided recombination creates an artificial family of cytochromes P450.Protein stability promotes evolvabilityCrystal structure of OxyB, a cytochrome P450 implicated in an oxidative phenol coupling reaction during vancomycin biosynthesisSubstrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis. Crystallographic, spectroscopic, and mutational studiesCrystal structure of human cytochrome P450 2C9 with bound warfarinCrystal structure of OxyC, a cytochrome P450 implicated in an oxidative C-C coupling reaction during vancomycin biosynthesisCharacterization of Active Site Structure in CYP121: A CYTOCHROME P450 ESSENTIAL FOR VIABILITY OF MYCOBACTERIUM TUBERCULOSIS H37RvCrystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1 H -imidazole: Ligand-Induced Structural Response through α-Helical Repositioning ,Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3Human Cytochrome P450 2E1 Structures with Fatty Acid Analogs Reveal a Previously Unobserved Binding ModeStructure, electronic properties and catalytic behaviour of an activity-enhancing CYP102A1 (P450(BM3)) variantConformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine MoleculesA Single Active-Site Mutation of P450BM-3 Dramatically Enhances Substrate Binding and Rate of Product FormationAn Enlarged, Adaptable Active Site in CYP164 Family P450 Enzymes, the Sole P450 in Mycobacterium lepraeStructural complex of sterol 14 -demethylase (CYP51) with 14 -methylenecyclopropyl- 7-24, 25-dihydrolanosterolStructure and function of CYP108D1 from Novosphingobium aromaticivorans DSM12444: an aromatic hydrocarbon-binding P450 enzymeStructural and Thermodynamic Basis of (+)-α-Pinene Binding to Human Cytochrome P450 2B6A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivoKey Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate BiasP450cin Active Site Water: Implications for Substrate Binding and Solvent AccessibilityStructure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and SerotoninP450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidationStructural evidence: a single charged residue affects substrate binding in cytochrome P450 BM-3Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculationsCrystal Structure of CYP106A2 in Substrate-Free and Substrate-Bound FormVariations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamilyEnsemble generation and the influence of protein flexibility on geometric tunnel prediction in cytochrome P450 enzymesEvolutionary history of a specialized p450 propane monooxygenaseNeutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution.Allosteric transitions in cytochrome P450eryF explored with pressure-perturbation spectroscopy, lifetime FRET, and a novel fluorescent substrate, Fluorol-7GA.The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexesHow does the reductase help to regulate the catalytic cycle of cytochrome P450 3A4 using the conserved water channel?Explicit water near the catalytic I helix Thr in the predicted solution structure of CYP2A4.Do mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling?Heme enzyme structure and function.Interactions of cytochrome P450s with their ligands.The interaction of microsomal cytochrome P450 2B4 with its redox partners, cytochrome P450 reductase and cytochrome b(5).New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.Dynamics and flexibility of human aromatase probed by FTIR and time resolved fluorescence spectroscopy
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Pivotal role of water in the mechanism of P450BM-3
@ast
Pivotal role of water in the mechanism of P450BM-3
@en
Pivotal role of water in the mechanism of P450BM-3
@nl
type
label
Pivotal role of water in the mechanism of P450BM-3
@ast
Pivotal role of water in the mechanism of P450BM-3
@en
Pivotal role of water in the mechanism of P450BM-3
@nl
prefLabel
Pivotal role of water in the mechanism of P450BM-3
@ast
Pivotal role of water in the mechanism of P450BM-3
@en
Pivotal role of water in the mechanism of P450BM-3
@nl
P2093
P356
P1433
P1476
Pivotal role of water in the mechanism of P450BM-3
@en
P2093
D C Haines
D R Tomchick
J A Peterson
P304
P356
10.1021/BI011197Q
P407
P577
2001-11-13T00:00:00Z