Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets

Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets

Item
http://www.wikidata.org/entity/Q27636521
Crystal structures of the FXIa catalytic domain in complex with ecotin mutants reveal substrate-like interactionsA urokinase-type plasminogen activator-inhibiting cyclic peptide with an unusual P2 residue and an extended protease binding surface demonstrates new modalities for enzyme inhibition.Contribution of explicit solvent effects to the binding affinity of small-molecule inhibitors in blood coagulation factor serine proteases.Hot spot analysis for driving the development of hits into leads in fragment-based drug discovery.Lessons from Hot Spot Analysis for Fragment-Based Drug Discovery.Application of a polarizable force field to calculations of relative protein-ligand binding affinitiesThe plasmin-antiplasmin system: structural and functional aspects.Natural and engineered plasmin inhibitors: applications and design strategies.Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation.Relationships between hydrogen bonds and halogen bonds in biological systems.Application of molecular modeling to urokinase inhibitors development.Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.Comparative binding energy analysis for binding affinity and target selectivity prediction.A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions.Structural model of haptoglobin and its complex with the anticoagulant ecotin variants: structure-activity relationship study and analysis of interactions.A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineeringTherapeutic applications of serine protease inhibitors
P2860

Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets

Item
http://www.wikidata.org/entity/Q27636521
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Engineering inhibitors highly ...... e serine protease drug targets
@ast
Engineering inhibitors highly ...... e serine protease drug targets
@en
Engineering inhibitors highly ...... e serine protease drug targets
@nl
type
label
Engineering inhibitors highly ...... e serine protease drug targets
@ast
Engineering inhibitors highly ...... e serine protease drug targets
@en
Engineering inhibitors highly ...... e serine protease drug targets
@nl
prefLabel
Engineering inhibitors highly ...... e serine protease drug targets
@ast
Engineering inhibitors highly ...... e serine protease drug targets
@en
Engineering inhibitors highly ...... e serine protease drug targets
@nl
P1433
P1476
P2093
P304
P31
P356
P433
P478
P577
P5875
P698
P356
P1433
P1476
Engineering inhibitors highly ...... e serine protease drug targets
@en
P2093
P304
P31
P356
10.1016/S1074-5521(01)00084-9
P433
P478
P577
P5875
P698