Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase
about
Human OGG1 undergoes serine phosphorylation and associates with the nuclear matrix and mitotic chromatin in vivoDynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variantKinetics of substrate recognition and cleavage by human 8-oxoguanine-DNA glycosylaseBase excision repair and cancerAutomated harvesting and processing of protein crystals through laser photoablationStructure of a trapped endonuclease III-DNA covalent intermediateDNA lesion recognition by the bacterial repair enzyme MutMStructural Characterization of Clostridium acetobutylicum 8-Oxoguanine DNA Glycosylase in Its Apo Form and in Complex with 8-OxodeoxyguanosineCrystal Structures of Two Archaeal 8-Oxoguanine DNA Glycosylases Provide Structural Insight into Guanine/8-Oxoguanine DistinctionStructural basis for the lack of opposite base specificity of Clostridium acetobutylicum 8-oxoguanine DNA glycosylaseThe C-terminal Lysine of Ogg2 DNA Glycosylases is a Major Molecular Determinant for Guanine/8-Oxoguanine DistinctionRepair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective miceDNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiaeRecent advances in the structural mechanisms of DNA glycosylasesEnumerating pathways of proton abstraction based on a spatial and electrostatic analysis of residues in the catalytic site.Thermodynamic and kinetic basis for recognition and repair of 8-oxoguanine in DNA by human 8-oxoguanine-DNA glycosylase.Thermodynamics of the DNA damage repair steps of human 8-oxoguanine DNA glycosylase.CUX2 protein functions as an accessory factor in the repair of oxidative DNA damage.8-oxoguanine DNA glycosylases: one lesion, three subfamiliesClostridium acetobutylicum 8-oxoguanine DNA glycosylase (Ogg) differs from eukaryotic Oggs with respect to opposite base discriminationCatalytic and DNA-binding properties of the human Ogg1 DNA N-glycosylase/AP lyase: biochemical exploration of H270, Q315 and F319, three amino acids of the 8-oxoguanine-binding pocket.DNA damage processing by human 8-oxoguanine-DNA glycosylase mutants with the occluded active site.The R46Q, R131Q and R154H polymorphs of human DNA glycosylase/beta-lyase hOgg1 severely distort the active site and DNA recognition site but do not cause unfolding.Substrate specificity and excision kinetics of natural polymorphic variants and phosphomimetic mutants of human 8-oxoguanine-DNA glycosylase.DNA base repair--recognition and initiation of catalysis.Mechanisms of base substitution mutagenesis in cancer genomes.Recognition of damaged DNA: structure and dynamic markers.Structural Features of the Interaction between Human 8-Oxoguanine DNA Glycosylase hOGG1 and DNA.Energetic preference of 8-oxoG eversion pathways in a DNA glycosylase.From face to interface recognition: a differential geometric approach to distinguish DNA from RNA binding surfaces.The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts.Mammalian 8-oxoguanine DNA glycosylase 1 incises 8-oxoadenine opposite cytosine in nuclei and mitochondria, while a different glycosylase incises 8-oxoadenine opposite guanine in nuclei.An open-label clinical trial assessing the efficacy and safety of Bend Skincare Anti-Aging Formula on minimal erythema dose in skin.Global DNA dynamics of 8-oxoguanine repair by human OGG1 revealed by stopped-flow kinetics and molecular dynamics simulation.Novel mutations of OGG1 base excision repair pathway gene in laryngeal cancer patients.Cloning and characterization of an ascidian homolog of the human 8-oxoguanine DNA glycosylase (Ogg1) that is involved in the repair of 8-oxo-7,8-dihydroguanine in DNA inCiona intestinalis
P2860
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P2860
Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Reciprocal "flipping" underlie ...... 8-oxo-guanine DNA glycosylase
@ast
Reciprocal "flipping" underlie ...... 8-oxo-guanine DNA glycosylase
@en
Reciprocal "flipping" underlie ...... 8-oxo-guanine DNA glycosylase
@nl
type
label
Reciprocal "flipping" underlie ...... 8-oxo-guanine DNA glycosylase
@ast
Reciprocal "flipping" underlie ...... 8-oxo-guanine DNA glycosylase
@en
Reciprocal "flipping" underlie ...... 8-oxo-guanine DNA glycosylase
@nl
prefLabel
Reciprocal "flipping" underlie ...... 8-oxo-guanine DNA glycosylase
@ast
Reciprocal "flipping" underlie ...... 8-oxo-guanine DNA glycosylase
@en
Reciprocal "flipping" underlie ...... 8-oxo-guanine DNA glycosylase
@nl
P2093
P356
P1476
Reciprocal "flipping" underlie ...... 8-oxo-guanine DNA glycosylase
@en
P2093
Erling Seeberg
Laurence H Pearl
Luisa Luna
Tracey E Barrett
P356
10.1006/JMBI.2002.5400
P407
P577
2002-03-22T00:00:00Z