Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis
about
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysisThe Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residueBacterial lipids: metabolism and membrane homeostasisThe short-chain oxidoreductase Q9HYA2 from Pseudomonas aeruginosa PAO1 contains an atypical catalytic centerStructure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 Å resolutionDiscovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosaStructure of a short-chain dehydrogenase/reductase from Bacillus anthracisCrystal structure of hexanoyl-CoA bound to β-ketoacyl reductase FabG4 of Mycobacterium tuberculosisStructural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preferenceInsights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenasePathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosisPhosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis3-oxoacyl-ACP reductase from Schistosoma japonicum: integrated in silico-in vitro strategy for discovering antischistosomal lead compoundsDissecting the Structural Elements for the Activation of β-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae.Structural elucidation of chalcone reductase and implications for deoxychalcone biosynthesis.Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin.Biochemical and genetic insights into asukamycin biosynthesis.The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define the specificity of the mycolic acid elongation complexes.Role of Serine140 in the mode of action of Mycobacterium tuberculosis β-ketoacyl-ACP Reductase (MabA)Comparative cell wall core biosynthesis in the mycolated pathogens, Mycobacterium tuberculosis and Corynebacterium diphtheriae.Targeting the formation of the cell wall core of M. tuberculosis.Recent advances in antituberculous drug development and novel drug targets.Protein targets for structure-based anti-Mycobacterium tuberculosis drug discovery.Fatty acid biosynthesis in actinomycetes.Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents.Development of new antituberculous agents based on new drug targets and structure-activity relationship.In vitro inhibition of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA by isoniazid.Crystallization and preliminary X-ray diffraction analysis of the high molecular weight ketoacyl reductase FabG4 complexed with NADH.Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis.Expression of 3-ketoacyl-acyl carrier protein reductase (fabG) genes enhances production of polyhydroxyalkanoate copolymer from glucose in recombinant Escherichia coli JM109Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity.Design, synthesis and characterization of novel inhibitors against mycobacterial β-ketoacyl CoA reductase FabG4.
P2860
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P2860
Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Crystal structure of MabA from ...... -chain fatty acid biosynthesis
@ast
Crystal structure of MabA from ...... -chain fatty acid biosynthesis
@en
Crystal structure of MabA from ...... -chain fatty acid biosynthesis
@nl
type
label
Crystal structure of MabA from ...... -chain fatty acid biosynthesis
@ast
Crystal structure of MabA from ...... -chain fatty acid biosynthesis
@en
Crystal structure of MabA from ...... -chain fatty acid biosynthesis
@nl
prefLabel
Crystal structure of MabA from ...... -chain fatty acid biosynthesis
@ast
Crystal structure of MabA from ...... -chain fatty acid biosynthesis
@en
Crystal structure of MabA from ...... -chain fatty acid biosynthesis
@nl
P2093
P921
P1476
Crystal structure of MabA from ...... -chain fatty acid biosynthesis
@en
P2093
Annaïk Quemard
Francois Hoh
Gilles Labesse
Martin Cohen-Gonsaud
Stéphanie Ducasse
P304
P356
10.1016/S0022-2836(02)00463-1
P407
P577
2002-07-05T00:00:00Z