Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis
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Probing a protein-protein interaction by in vitro evolutionOrigins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domainExploring the Capacity of Minimalist Protein Interfaces: Interface Energetics and Affinity Maturation to Picomolar KD of a Single-domain Antibody with a Flat ParatopeStructural and functional analysis of the PDZ domains of human HtrA1 and HtrA3Matuzumab Binding to EGFR Prevents the Conformational Rearrangement Required for DimerizationHigh Resolution NMR-based Model for the Structure of a scFv-IL-1 Complex: POTENTIAL FOR NMR AS A KEY TOOL IN THERAPEUTIC ANTIBODY DESIGN AND DEVELOPMENTMolecular Basis of a Million-Fold Affinity Maturation Process in a Protein–Protein InteractionInhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon ReceptorCross-Neutralising Nanobodies Bind to a Conserved Pocket in the Hemagglutinin Stem Region Identified Using Yeast Display and Deep Mutational Scanning.Phage display of random peptide libraries: applications, limits, and potential.Exploring protein-protein interactions with phage display.Phage-display as a tool for quantifying protein stability determinants.Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis.Exploring the interaction between the protein kinase A catalytic subunit and caveolin-1 scaffolding domain with shotgun scanning, oligomer complementation, NMR, and dockingComprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning.Optimizing the affinity and specificity of proteins with molecular display.Fine and domain-level epitope mapping of botulinum neurotoxin type A neutralizing antibodies by yeast surface display.Synthetic antibodies as therapeutics.Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.Peptide probes derived from pertuzumab by molecular dynamics modeling for HER2 positive tumor imaging.Contribution of light chain residues to high affinity binding in an HIV-1 antibody explored by combinatorial scanning mutagenesisConstruction of a stability landscape of the CH3 domain of human IgG1 by combining directed evolution with high throughput sequencing.Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challengeA consensus method for the prediction of 'aggregation-prone' peptides in globular proteins.Side chain requirements for affinity and specificity in D5, an HIV-1 antibody derived from the VH1-69 germline segmentA two-in-one antibody engineered from a humanized interleukin 4 antibody through mutation in heavy chain complementarity-determining regions.High-throughput biotinylation of proteins.Synthetic antibodies and peptides recognizing progressive multifocal leukoencephalopathy-specific point mutations in polyomavirus JC capsid viral protein 1.Comprehensive mapping of functional epitopes on dengue virus glycoprotein E DIII for binding to broadly neutralizing antibodies 4E11 and 4E5A by phage display.Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies.Synthetic human monoclonal antibodies toward staphylococcal enterotoxin B (SEB) protective against toxic shock syndromeAnalysis of the neutralization breadth of the anti-V3 antibody F425-B4e8 and re-assessment of its epitope fine specificity by scanning mutagenesis.Double barrel shotgun scanning of the caveolin-1 scaffolding domain.Integrated prediction of the effect of mutations on multiple protein characteristics.
P2860
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P2860
Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Comprehensive functional maps ...... h shotgun scanning mutagenesis
@ast
Comprehensive functional maps ...... h shotgun scanning mutagenesis
@en
Comprehensive functional maps ...... h shotgun scanning mutagenesis
@nl
type
label
Comprehensive functional maps ...... h shotgun scanning mutagenesis
@ast
Comprehensive functional maps ...... h shotgun scanning mutagenesis
@en
Comprehensive functional maps ...... h shotgun scanning mutagenesis
@nl
prefLabel
Comprehensive functional maps ...... h shotgun scanning mutagenesis
@ast
Comprehensive functional maps ...... h shotgun scanning mutagenesis
@en
Comprehensive functional maps ...... h shotgun scanning mutagenesis
@nl
P2093
P3181
P1476
Comprehensive functional maps ...... h shotgun scanning mutagenesis
@en
P2093
Abraham M de Vos
Camellia W Adams
Felix F Vajdos
Leonard G Presta
Sachdev S Sidhu
Timothy N Breece
P304
P3181
P356
10.1016/S0022-2836(02)00264-4
P407
P577
2002-07-05T00:00:00Z