Structure of the LDL receptor extracellular domain at endosomal pH
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The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pitsStructural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pHSecreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic miceMutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q.LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeatA pH-regulated dimeric bouquet in the structure of von Willebrand factorSpecificity of binding of the low density lipoprotein receptor-related protein to different conformational states of the clade E serpins plasminogen activator inhibitor-1 and proteinase nexin-1Monogenic hypercholesterolemia: new insights in pathogenesis and treatmentStructure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptorsCa2+ binding to complement-type repeat domains 5 and 6 from the low-density lipoprotein receptor-related proteinStructural Insights into Reelin Function: Present and FutureLow Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell FunctionThe use of polyoxometalates in protein crystallography – An attempt to widen a well-known bottleneckHypercholesterolemia, low density lipoprotein receptor and proprotein convertase subtilisin/kexin-type 9Proprotein convertase subtilisin/kexin type 9: from the discovery to the development of new therapies for cardiovascular diseasesStructural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemiaThe structure of receptor-associated protein (RAP)Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switchMolecular basis for LDL receptor recognition by PCSK9Structure and dynamics of human apolipoprotein CIIIStructural Insight into the Mechanisms of Wnt Signaling Antagonism by DkkAntagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 CellsStructure of the Minimal Interface Between ApoE and LRPCrystal structures of the extracellular domain of LRP6 and its complex with DKK1Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt SignalingStructural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6The Structure, Dynamics, and Binding of the LA45 Module Pair of the Low-Density Lipoprotein Receptor Suggest an Important Role for LA4 in Ligand ReleaseGentamicin Binds to the Megalin Receptor as a Competitive Inhibitor Using the Common Ligand Binding Motif of Complement Type Repeats: INSIGHT FROM THE NMR STRUCTURE OF THE 10TH COMPLEMENT TYPE REPEAT DOMAIN ALONE AND IN COMPLEX WITH GENTAMICINStructural basis of agrin-LRP4-MuSK signalingStructural Characterization of Carbohydrate Binding by LMAN1 Protein Provides New Insight into the Endoplasmic Reticulum Export of Factors V (FV) and VIII (FVIII)Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tailRisk factor SORL1: from genetic association to functional validation in Alzheimer's diseaseThe closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosomeAdaptor protein ARH is recruited to the plasma membrane by low density lipoprotein (LDL) binding and modulates endocytosis of the LDL/LDL receptor complex in hepatocytesCrystal structure of the Kelch domain of human Keap1Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptorAgrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK)LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein traffickingMouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues
P2860
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P2860
Structure of the LDL receptor extracellular domain at endosomal pH
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Structure of the LDL receptor extracellular domain at endosomal pH
@ast
Structure of the LDL receptor extracellular domain at endosomal pH
@en
Structure of the LDL receptor extracellular domain at endosomal pH
@nl
type
label
Structure of the LDL receptor extracellular domain at endosomal pH
@ast
Structure of the LDL receptor extracellular domain at endosomal pH
@en
Structure of the LDL receptor extracellular domain at endosomal pH
@nl
prefLabel
Structure of the LDL receptor extracellular domain at endosomal pH
@ast
Structure of the LDL receptor extracellular domain at endosomal pH
@en
Structure of the LDL receptor extracellular domain at endosomal pH
@nl
P2093
P50
P3181
P356
P1433
P1476
Structure of the LDL receptor extracellular domain at endosomal pH
@en
P2093
Gabby Rudenko
Keith Henderson
Lisa Henry
Michael S Brown
P304
P3181
P356
10.1126/SCIENCE.1078124
P407
P577
2002-12-20T00:00:00Z