X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha - Wikidata - awgldk - TriplyDB

X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha

X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha

http://www.wikidata.org/entity/Q27640112

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Identification of an endogenous ligand bound to a native orphan nuclear receptor Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivation Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands Orphan nuclear receptors in drug discovery Potential roles of ROR-alpha in cardiovascular endocrinology.Insights into Orphan Nuclear Receptors as Prognostic Markers and Novel Therapeutic Targets for Breast Cancer ROR nuclear receptors: structures, related diseases, and drug discovery Regulation of the cytosolic sulfotransferases by nuclear receptors The therapeutic potential of RORγ modulators in the treatment of human disease Comparative Analyses of QTLs Influencing Obesity and Metabolic Phenotypes in Pigs and Humans X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms Structural Basis of Digoxin That Antagonizes ROR t Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production Chemical chronobiology: Toward drugs manipulating time.Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism Retinoic acid actions through mammalian nuclear receptors.The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors.Nuclear receptors: the evolution of diversity.Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: a systems biology based approach Site-specific impacts on gene expression and behavior in fathead minnows (Pimephales promelas) exposed in situ to streams adjacent to sewage treatment plants The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in Drosophila Regulation of steroidogenic acute regulatory protein transcription in largemouth bass by orphan nuclear receptor signaling pathways.Biophysical studies of cholesterol effects on chromatin The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D.Development of an HTS-compatible assay for discovery of RORα modulators using AlphaScreen® technology.The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.Native MS: an 'ESI' way to support structure- and fragment-based drug discovery.A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol)Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics Transcriptional regulation of human hydroxysteroid sulfotransferase SULT2A1 by LXRα.Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα)Action of RORs and their ligands in (patho)physiology.Structural basis for HNF-4alpha activation by ligand and coactivator binding.Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases.Structural and functional insights into nuclear receptor signaling.REV-ERB and ROR nuclear receptors as drug targets.

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X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha

http://www.wikidata.org/entity/Q27640112

description

2002 nî lūn-bûn

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2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

X-ray structure of the hRORalp ...... the natural ligand of RORalpha

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X-ray structure of the hRORalp ...... the natural ligand of RORalpha

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X-ray structure of the hRORalp ...... the natural ligand of RORalpha

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X-ray structure of the hRORalp ...... the natural ligand of RORalpha

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X-ray structure of the hRORalp ...... the natural ligand of RORalpha

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X-ray structure of the hRORalp ...... the natural ligand of RORalpha

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X-ray structure of the hRORalp ...... the natural ligand of RORalpha

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X-ray structure of the hRORalp ...... the natural ligand of RORalpha

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X-ray structure of the hRORalp ...... the natural ligand of RORalpha

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X-ray structure of the hRORalp ...... the natural ligand of RORalpha

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Brigitte Fournier

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Francis Bitsch

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Isabelle Delhon

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Jean-Marc Schlaeppi

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Joerg A Kallen

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Martin Geiser

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Sabine Geisse

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