The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography
about
Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscodingAntibiotics that target protein synthesisStructure of the Antibiotic Resistance Factor Spectinomycin Phosphotransferase from Legionella pneumophilaDevelopment of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutationsThree-dimensional motifs from the SCOR, structural classification of RNA database: extruded strands, base triples, tetraloops and U-turnsNovel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.Characterization of ribosomal binding and antibacterial activities using two orthogonal high-throughput screensDrug target interaction energies by the kernel energy method in aminoglycoside drugs and ribosomal A site RNA targets.Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases.Surprising alteration of antibacterial activity of 5"-modified neomycin against resistant bacteria.Synthesis and antibacterial activity of pyranmycin derivatives with N-1 and O-6 modifications.Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase.Aminoglycosides: molecular insights on the recognition of RNA and aminoglycoside mimics.Quantum kernel applications in medicinal chemistry.The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6'-N-acetyltransferase and the role of 6'-NH2 in antibacterial activityAntibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site.Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.Amikacin: Uses, Resistance, and Prospects for Inhibition.Potential new antibiotic sites in the ribosome revealed by deleterious mutations in RNA of the large ribosomal subunit.
P2860
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P2860
The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography
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2003 nî lūn-bûn
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2003 թուականի Մարտին հրատարակուած գիտական յօդուած
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2003 թվականի մարտին հրատարակված գիտական հոդված
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2003年の論文
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2003年論文
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2003年論文
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2003年論文
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2003年論文
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name
The complex of a designer anti ...... ealed by X-ray crystallography
@ast
The complex of a designer anti ...... ealed by X-ray crystallography
@en
The complex of a designer anti ...... ealed by X-ray crystallography
@nl
type
label
The complex of a designer anti ...... ealed by X-ray crystallography
@ast
The complex of a designer anti ...... ealed by X-ray crystallography
@en
The complex of a designer anti ...... ealed by X-ray crystallography
@nl
prefLabel
The complex of a designer anti ...... ealed by X-ray crystallography
@ast
The complex of a designer anti ...... ealed by X-ray crystallography
@en
The complex of a designer anti ...... ealed by X-ray crystallography
@nl
P2093
P356
P1476
The complex of a designer anti ...... ealed by X-ray crystallography
@en
P2093
Georg Lentzen
Jalal Haddad
James B Murray
Rupert J M Russell
P304
P356
10.1021/JA029736H
P407
P577
2003-03-26T00:00:00Z