Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition
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Crystal Structure of the Geobacillus stearothermophilus Carboxylesterase Est55 and Its Activation of Prodrug CPT-11Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun † , ‡Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent SarinIdentification of human IKK-2 inhibitors of natural origin (part I): modeling of the IKK-2 kinase domain, virtual screening and activity assaysInactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2.Structural basis for inhibition of histamine N-methyltransferase by diverse drugsEvolution of protein binding modes in homooligomers.Carboxylesterases: Dual roles in lipid and pesticide metabolism.Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound implications in the activation of anticancer prodrugs.Porcine Liver Carboxylesterase Requires Polyisoprenylation for High Affinity Binding to Cysteinyl Substrates.Synergistic effects of clopidogrel and fufang danshen dripping pills by modulation of the metabolism target and pharmacokineticsLipophilic prodrug conjugates allow facile and rapid synthesis of high-loading capacity liposomes without the need for post-assembly purification.Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1Crystal Structure and Functional Characterization of an Esterase (EaEST) from Exiguobacterium antarcticum.Specificity in molecular design: a physical framework for probing the determinants of binding specificity and promiscuity in a biological environment.Optimal drug cocktail design: methods for targeting molecular ensembles and insights from theoretical model systems.In Silico Design and Evaluation of Carboxylesterase Inhibitors.Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism.Inhibition of polyisoprenylated methylated protein methyl esterase by synthetic musks induces cell degeneration.Design, synthesis, and preliminary evaluation of doxazolidine carbamates as prodrugs activated by carboxylesterasesNeural stem cell-mediated delivery of irinotecan-activating carboxylesterases to glioma: implications for clinical use.Nuclear receptor-mediated regulation of carboxylesterase expression and activity.Biochemical and docking analysis of substrate interactions with polyisoprenylated methylated protein methyl esterase.Carboxylesterase inhibitors.Glycoengineering of Esterase Activity through Metabolic Flux-Based Modulation of Sialic Acid.Carboxylesterases: General detoxifying enzymes.Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance.Carboxylesterases in lipid metabolism: from mouse to human.Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles.Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity.Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1.Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.Liver prenylated methylated protein methyl esterase is the same enzyme as Sus scrofa carboxylesterase.Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin.Exploring different virtual screening strategies for acetylcholinesterase inhibitors.Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer's drugs: a computational investigation.CES1 trimer.CES2 hydrolyse COCN to BEGFacile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors.Esterase from a cariogenic bacterium hydrolyzes dental resins.
P2860
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P2860
Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Crystal structure of human car ...... scuity to selective inhibition
@ast
Crystal structure of human car ...... scuity to selective inhibition
@en
Crystal structure of human car ...... scuity to selective inhibition
@nl
type
label
Crystal structure of human car ...... scuity to selective inhibition
@ast
Crystal structure of human car ...... scuity to selective inhibition
@en
Crystal structure of human car ...... scuity to selective inhibition
@nl
prefLabel
Crystal structure of human car ...... scuity to selective inhibition
@ast
Crystal structure of human car ...... scuity to selective inhibition
@en
Crystal structure of human car ...... scuity to selective inhibition
@nl
P2093
P1476
Crystal structure of human car ...... scuity to selective inhibition
@en
P2093
Christopher L Morton
Janice L Hyatt
Mary K Danks
Peter Kuhn
Sompop Bencharit
P304
P356
10.1016/S1074-5521(03)00071-1
P577
2003-04-01T00:00:00Z