The structural basis for the selectivity of benzotriazole inhibitors of PTP1B

The structural basis for the selectivity of benzotriazole inhibitors of PTP1B

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http://www.wikidata.org/entity/Q27642236
Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transductionNitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition stateResidues distant from the active site influence protein-tyrosine phosphatase 1B inhibitor binding.Identification of ligand binding sites of proteins using the Gaussian Network Model.Recent advances in protein tyrosine phosphatase 1B inhibitors.New Frontiers in DruggabilityDesign, synthesis, biological activity and molecular dynamics studies of specific protein tyrosine phosphatase 1B inhibitors over SHP-2Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development.Molecular Pathways: Targeting Protein Tyrosine Phosphatases in Cancer.Druggability analysis and classification of protein tyrosine phosphatase active sites.Classification of binding site conformations of protein tyrosine phosphatase 1B.Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase.Design and synthesis of imidazolidine-2,4-dione derivatives as selective inhibitors by targeting protein tyrosine phosphatase-1B over T-cell protein tyrosine phosphatase.Prediction of enzyme inhibition and mode of inhibitory action based on calculation of distances between hydrogen bond donor/acceptor groups of the molecule and docking analysis: An application on the discovery of novel effective PTP1B inhibitors.Copper-catalyzed cascade cyclization reaction of 2-haloaryltriazenes and sodium azide: selective synthesis of 2H-benzotriazoles in water.Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors.Allosteric binding sites in Rab11 for potential drug candidates.
P2860

The structural basis for the selectivity of benzotriazole inhibitors of PTP1B

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http://www.wikidata.org/entity/Q27642236
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2003 nî lūn-bûn
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2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
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2003年論文
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2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B
@ast
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B
@en
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B
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type
label
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B
@ast
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B
@en
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B
@nl
prefLabel
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B
@ast
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B
@en
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B
@nl
P1433
P1476
P2093
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P698
P3181
P356
P1433
P1476
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B
@en
P2093
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P698