2.0A resolution crystal structures of the ternary complexes of human phenylalanine hydroxylase catalytic domain with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine or L-norleucine...
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Activation of phenylalanine hydroxylase induces positive cooperativity toward the natural cofactorEvidence for a high-spin Fe(IV) species in the catalytic cycle of a bacterial phenylalanine hydroxylaseRegulation of phenylalanine hydroxylase: conformational changes upon phenylalanine binding detected by hydrogen/deuterium exchange and mass spectrometryStructure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stabilityMechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic AnalysisStructural and mechanistic basis of the interaction between a pharmacological chaperone and human phenylalanine hydroxylaseAn additional substrate binding site in a bacterial phenylalanine hydroxylaseStructural and thermodynamic insight into phenylalanine hydroxylase from the human pathogenLegionella pneumophilaStructural insights into the regulation of aromatic amino acid hydroxylationSpectroscopy and kinetics of wild-type and mutant tyrosine hydroxylase: mechanistic insight into O2 activationReduction and oxidation of the active site iron in tyrosine hydroxylase: kinetics and specificityFormation of the iron-oxo hydroxylating species in the catalytic cycle of aromatic amino acid hydroxylases.Mechanisms of tryptophan and tyrosine hydroxylase.A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis.Dynamic regulation of phenylalanine hydroxylase by simulated redox manipulationPhenylalanine hydroxylase misfolding and pharmacological chaperones.Boosting serotonin in the brain: is it time to revamp the treatment of depression?Active-site structure of a β-hydroxylase in antibiotic biosynthesisSpectroscopic and electronic structure studies of aromatic electrophilic attack and hydrogen-atom abstraction by non-heme iron enzymesLoss of function in phenylketonuria is caused by impaired molecular motions and conformational instabilityDomain Movements upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-ray Scattering.Versatility of biological non-heme Fe(II) centers in oxygen activation reactions.Pulsed EPR study of amino acid and tetrahydropterin binding in a tyrosine hydroxylase nitric oxide complex: evidence for substrate rearrangements in the formation of the oxygen-reactive complex.First- and second-sphere contributions to Fe(II) site activation by cosubstrate binding in non-heme Fe enzymes.Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations.Allosteric regulation of phenylalanine hydroxylase.Substituting Tyr138 in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation.Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center.Dioxygen activation by nonheme iron enzymes with the 2-His-1-carboxylate facial triad that generate high-valent oxoiron oxidants.Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain.Measurement of the intramolecular isotope effect on aliphatic hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase.Computational study of missense mutations in phenylalanine hydroxylase.Stabilization of tryptophan hydroxylase 2 by l-phenylalanine-induced dimerization.Kinetic mechanism of phenylalanine hydroxylase: intrinsic binding and rate constants from single-turnover experiments.Effects of ligands on the mobility of an active-site loop in tyrosine hydroxylase as monitored by fluorescence anisotropy.Mutagenesis of a specificity-determining residue in tyrosine hydroxylase establishes that the enzyme is a robust phenylalanine hydroxylase but a fragile tyrosine hydroxylasePredicted effects of missense mutations on native-state stability account for phenotypic outcome in phenylketonuria, a paradigm of misfolding diseases.Regulation of phenylalanine hydroxylase: conformational changes upon phosphorylation detected by H/D exchange and mass spectrometry.Characterization of metal ligand mutants of phenylalanine hydroxylase: Insights into the plasticity of a 2-histidine-1-carboxylate triad.PKU mutation p.G46S prevents the stereospecific binding of l-phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain.
P2860
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P2860
2.0A resolution crystal structures of the ternary complexes of human phenylalanine hydroxylase catalytic domain with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine or L-norleucine...
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
2.0A resolution crystal struct ...... )-L-alanine or L-norleucine...
@ast
2.0A resolution crystal struct ...... )-L-alanine or L-norleucine...
@en
2.0A resolution crystal struct ...... )-L-alanine or L-norleucine...
@nl
type
label
2.0A resolution crystal struct ...... )-L-alanine or L-norleucine...
@ast
2.0A resolution crystal struct ...... )-L-alanine or L-norleucine...
@en
2.0A resolution crystal struct ...... )-L-alanine or L-norleucine...
@nl
prefLabel
2.0A resolution crystal struct ...... )-L-alanine or L-norleucine...
@ast
2.0A resolution crystal struct ...... )-L-alanine or L-norleucine...
@en
2.0A resolution crystal struct ...... )-L-alanine or L-norleucine...
@nl
P2093
P3181
P1476
2.0A resolution crystal struct ...... s related to substrate binding
@en
P2093
Anne J Stokka
Edward Hough
Torgeir Flatmark
P304
P3181
P356
10.1016/J.JMB.2003.09.004
P407
P577
2003-10-01T00:00:00Z