Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat
about
The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1Structural Studies on Dinuclear Ruthenium(II) Complexes That Bind Diastereoselectively to an Antiparallel Folded Human Telomere SequenceSolution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC(3)NMR Structure of a Triangulenium-Based Long-Lived Fluorescence Probe Bound to a G-QuadruplexDistance measurements between paramagnetic ligands bound to parallel stranded guanine quadruplexesTelomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effectTargeting human telomerase for cancer therapeutics.Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: II. The binding characterization with specific intramolecular G-quadruplex and the recognizing mechanismChemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.Polycyclic azoniahetarenes: assessing the binding parameters of complexes between unsubstituted ligands and G-quadruplex DNA.Bcl-2 promoter sequence G-quadruplex interactions with three planar and non-planar cationic porphyrins: TMPyP4, TMPyP3, and TMPyP2.Identification of new natural DNA G-quadruplex binders selected by a structure-based virtual screening approach.Dominant Driving Forces in Human Telomere Quadruplex Binding-Induced Structural Alterations.Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement.11-Substituted Benzo[c]phenanthridines: New Structures and Insight into Their Mode of Antiproliferative Action.DNA architecture: from G to Z.Ruthenium Complex "Light Switches" that are Selective for Different G-Quadruplex Structures.Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solutionHuman telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.A hitchhiker's guide to G-quadruplex ligands.On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium saltsSupramolecular polymer formation by cyclic dinucleotides and intercalators affects dinucleotide enzymatic processingIntramolecular quadruplex conformation of human telomeric DNA assessed with 125I-radioprobing.Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations.Dynamics of telomeric chromatin at the crossroads of aging and cancer.Telomeres as targets for anticancer therapies.Methods for investigating G-quadruplex DNA/ligand interactions.G-quadruplexes as potential therapeutic targets for embryonal tumors.Studies on the site and mode of TMPyP4 interactions with Bcl-2 promoter sequence G-Quadruplexes.Seven essential questions on G-quadruplexes.Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifsRecent advances in targeting the telomeric G-quadruplex DNA sequence with small molecules as a strategy for anticancer therapies.G-quadruplex nucleic acids as therapeutic targets.Classification of g-quadruplex DNA on the basis of the quadruplex twist angle and planarity of g-quartets.DSC deconvolution of the structural complexity of c-MYC P1 promoter G-quadruplexes.PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy.Molecular docking based screening of triterpenoids as potential G-quadruplex stabilizing ligands with anti-cancer activity.Binding modes and pathway of RHPS4 to human telomeric G-quadruplex and duplex DNA probed by all-atom molecular dynamics simulations with explicit solvent.Impact of planarity of unfused aromatic molecules on G-quadruplex binding: learning from isaindigotone derivatives.
P2860
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P2860
Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Drug recognition and stabilisa ...... ing the human telomeric repeat
@ast
Drug recognition and stabilisa ...... ing the human telomeric repeat
@en
Drug recognition and stabilisa ...... ing the human telomeric repeat
@nl
type
label
Drug recognition and stabilisa ...... ing the human telomeric repeat
@ast
Drug recognition and stabilisa ...... ing the human telomeric repeat
@en
Drug recognition and stabilisa ...... ing the human telomeric repeat
@nl
prefLabel
Drug recognition and stabilisa ...... ing the human telomeric repeat
@ast
Drug recognition and stabilisa ...... ing the human telomeric repeat
@en
Drug recognition and stabilisa ...... ing the human telomeric repeat
@nl
P1476
Drug recognition and stabilisa ...... ing the human telomeric repeat
@en
P2093
Malcolm F G Stevens
Robert A Heald
P356
10.1016/J.JMB.2003.09.018
P407
P577
2003-11-01T00:00:00Z