Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor
about
Binding isotope effects: boon and baneStructures of native human thymidine phosphorylase and in complex with 5-iodouracil3'-Azidothymidine in the active site of Escherichia coli thymidine phosphorylase: the peculiarity of the binding on the basis of X-ray studyThe role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression.Purification, crystallization and preliminary X-ray diffraction study on pyrimidine nucleoside phosphorylase TTHA1771 from Thermus thermophilus HB8A kinetic, modeling and mechanistic re-analysis of thymidine phosphorylase and some related enzymes.Transition States, analogues, and drug development.Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug designStructural investigation of the thymidine phosphorylase from Salmonella typhimurium in the unliganded state and its complexes with thymidine and uridine.Indispensable residue for uridine binding in the uridine-cytidine kinase family.Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues.Synthesis and in vitro evaluation of 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives as thymidine phosphorylase inhibitors.The nucleoside derivative 5'-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action.Thymidine phosphorylase: A potential new target for treating cardiovascular disease.Syntheses of 1-[2-(Phosphonomethoxy)Alkyl] thymine monophosphates and an evaluation of their inhibitory activity toward human thymidine phosphorylase.6-substituted 5-fluorouracil derivatives as transition state analogue inhibitors of thymidine phosphorylase.thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphatethymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphateDesign, synthesis and enzymatic evaluation of 6-bridged imidazolyluracil derivatives as inhibitors of human thymidine phosphorylase.Structural and Mutational Analysis of Substrate Complexation by Anthranilate Phosphoribosyltransferase fromSulfolobus solfataricus
P2860
Q24681941-F77A2035-DD31-4A0F-B31F-15010E0CE539Q27646320-47705EE4-DCD5-43F1-B589-684FB7CAD47CQ27690000-3C95D029-FBCB-4B6D-B0FC-A5EF89A5E143Q35951880-36B1A897-28D0-4E63-A86A-7F04982553A4Q36580625-8A0FE08A-1421-438B-9F35-DAC4B7C4955DQ36694517-A0D74399-03BC-435B-9BBB-469F3BC81E24Q38069211-4ABF628E-491B-4D91-8A6A-DBA91473FC05Q38663123-53F2258C-B87C-4A92-9917-43C3120052C0Q40776066-0D3AAF6A-C877-4AD6-923D-0C8D87FF67E4Q41682081-96BD82C3-3802-45EA-9918-5D62AE4C505EQ42719375-F06CED0C-0D84-4F80-9DDB-C06C10F14617Q44117141-31FEFCA3-5588-43E0-95C2-5187D93C8289Q44881139-3C223714-4946-49E9-A01A-419B20F58C8AQ45305297-697147D9-B55C-49E4-9D07-7E536A8DD849Q45731665-EA92741C-C677-43F3-BA69-61473F635719Q46773128-F04CD444-6718-4A25-B640-C4281D5DCC51Q50294622-89CC6355-46BF-44F2-8B0C-C28A1240360AQ50294675-F9F501C0-D0DB-408F-B67D-10A99CDF7C4CQ53742004-BA28D460-E767-4531-A6C7-AB243A4E2520Q57091000-AE67CB0A-A787-4A20-A4BD-2FF3BD38301B
P2860
Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Crystal structure of human thy ...... ith a small molecule inhibitor
@ast
Crystal structure of human thy ...... ith a small molecule inhibitor
@en
Crystal structure of human thy ...... ith a small molecule inhibitor
@nl
type
label
Crystal structure of human thy ...... ith a small molecule inhibitor
@ast
Crystal structure of human thy ...... ith a small molecule inhibitor
@en
Crystal structure of human thy ...... ith a small molecule inhibitor
@nl
prefLabel
Crystal structure of human thy ...... ith a small molecule inhibitor
@ast
Crystal structure of human thy ...... ith a small molecule inhibitor
@en
Crystal structure of human thy ...... ith a small molecule inhibitor
@nl
P2093
P1433
P1476
Crystal structure of human thy ...... ith a small molecule inhibitor
@en
P2093
Claire A Minshull
David Timms
Dougie S Paterson
Eileen J McCall
Helen H J McMiken
Jason Breed
Jeremy G Colls
Julie A Tucker
Mark S B McAlister
Michael Bate
P356
10.1016/J.STR.2003.11.018
P577
2004-01-01T00:00:00Z