Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper
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IRAK signalling in cancerBenzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein–ligand crystallographyStructural Analysis of Pseudomonas syringae AvrPtoB Bound to Host BAK1 Reveals Two Similar Kinase-Interacting Domains in a Type III EffectorCrystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiationRecent Progress in the Molecular Recognition and Therapeutic Importance of Interleukin-1 Receptor-Associated Kinase 4IRAK4 dimerization and trans-autophosphorylation are induced by Myddosome assemblyIRAK-4 inhibitors for inflammationIdentifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinasesDual Inhibition of Rip2 and IRAK1/4 Regulates IL-1β and IL-6 in Sarcoidosis Alveolar Macrophages and Peripheral Blood Mononuclear CellsAn innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2Structural dynamic analysis of apo and ATP-bound IRAK4 kinaseConserved threonine residues within the A-loop of the receptor NIK differentially regulate the kinase function required for antiviral signalingHost MicroRNA-217 Promotes White Spot Syndrome Virus Infection by Targeting Tube in the Chinese Mitten Crab (Eriocheir sinensis).Identification of critical functional residues of receptor-like kinase ERECTA.A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.Molecular evolution and structural features of IRAK family members.The Arabidopsis thaliana SERK1 kinase domain spontaneously refolds to an active state in vitro.Structure-function similarities between a plant receptor-like kinase and the human interleukin-1 receptor-associated kinase-4.A nonsynonymous polymorphism of IRAK4 associated with increased prevalence of gram-positive infection and decreased response to toll-like receptor ligandsDiscovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.Crystallization and preliminary crystallographic analysis of Arabidopsis thaliana BRI1-associated kinase 1 (BAK1) cytoplasmic domainStructural and mechanistic insights into the bifunctional enzyme isocitrate dehydrogenase kinase/phosphatase AceK.Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors.Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy.Structural Characterization of Maize SIRK1 Kinase Domain Reveals an Unusual Architecture of the Activation Segment.Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFATThe involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellular signaling networks controlling inflammationTargeting Toll-like receptors for treatment of SLEToll-like receptor signaling pathways--therapeutic opportunities.Comparison of moonlighting guanylate cyclases: roles in signal direction?Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Autophosphorylation of gatekeeper tyrosine by symbiosis receptor kinase.A novel aminosaccharide compound blocks immune responses by Toll-like receptors and nucleotide-binding domain, leucine-rich repeat proteins.Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific mannerThe IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression.In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance.Molecular characterization and comparative sequence analysis of defense-related gene, Oryza rufipogon receptor-like protein kinase 1.
P2860
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P2860
Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Crystal structures of IRAK-4 k ...... with tyrosine as a gatekeeper
@ast
Crystal structures of IRAK-4 k ...... with tyrosine as a gatekeeper
@en
Crystal structures of IRAK-4 k ...... with tyrosine as a gatekeeper
@nl
type
label
Crystal structures of IRAK-4 k ...... with tyrosine as a gatekeeper
@ast
Crystal structures of IRAK-4 k ...... with tyrosine as a gatekeeper
@en
Crystal structures of IRAK-4 k ...... with tyrosine as a gatekeeper
@nl
prefLabel
Crystal structures of IRAK-4 k ...... with tyrosine as a gatekeeper
@ast
Crystal structures of IRAK-4 k ...... with tyrosine as a gatekeeper
@en
Crystal structures of IRAK-4 k ...... with tyrosine as a gatekeeper
@nl
P2093
P1433
P1476
Crystal structures of IRAK-4 k ...... with tyrosine as a gatekeeper
@en
P2093
Athena Sudom
Holger Wesche
Jay P Powers
Jinsong Liu
Merrill Ayres
Nigel P C Walker
Zhulun Wang
P304
P356
10.1016/J.STR.2006.11.001
P407
P577
2006-12-01T00:00:00Z