Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism
about
Apo-Human Carbonic Anhydrase II Revisited: Implications of the Loss of a Metal in Protein Structure, Stability, and Solvent Network ,Entrapment of Carbon Dioxide in the Active Site of Carbonic Anhydrase IIRole of Hydrophilic Residues in Proton Transfer during Catalysis by Human Carbonic Anhydrase II † ‡Design of a Carbonic Anhydrase IX Active-Site Mimic To Screen Inhibitors for Possible Anticancer Properties † ‡High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug designA Short, Strong Hydrogen Bond in the Active Site of Human Carbonic Anhydrase IINeutron Structure of Human Carbonic Anhydrase II: Implications for Proton TransferAtomic resolution studies of carbonic anhydrase IIStructural and Kinetic Study of the Extended Active Site for Proton Transfer in Human Carbonic Anhydrase IICoumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigationsComparison of solution and crystal properties of Co(II)–substituted human carbonic anhydrase IIKinetic and crystallographic studies of the role of tyrosine 7 in the active site of human carbonic anhydrase IIStructure and catalysis by carbonic anhydrase II: Role of active-site tryptophan 5Water Networks in Fast Proton Transfer during Catalysis by Human Carbonic Anhydrase IIKinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase IIX-ray structure of the first `extremo-α-carbonic anhydrase', a dimeric enzyme from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazolesProbing the surface of human carbonic anhydrase for clues towards the design of isoform specific inhibitorsStructural and catalytic effects of proline substitution and surface loop deletion in the extended active site of human carbonic anhydrase IIModification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity.Coupling Protein Dynamics with Proton Transport in Human Carbonic Anhydrase II.NMR studies of active-site properties of human carbonic anhydrase II by using (15) N-labeled 4-methylimidazole as a local probe and histidine hydrogen-bond correlations.Joint neutron crystallographic and NMR solution studies of Tyr residue ionization and hydrogen bonding: Implications for enzyme-mediated proton transfer.Proton transport in carbonic anhydrase: Insights from molecular simulation.Structure of a monoclinic polymorph of human carbonic anhydrase II with a doubled a axis.Intrinsic proton-donating power of zinc-bound water in a carbonic anhydrase active site model estimated by NMR.Chemical rescue of enzymes: proton transfer in mutants of human carbonic anhydrase II.Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II.Comparison and analysis of zinc and cobalt-based systems as catalytic entities for the hydration of carbon dioxideAnalysis of the binding moiety mediating the interaction between monocarboxylate transporters and carbonic anhydrase IIInsights towards sulfonamide drug specificity in α-carbonic anhydrasesTracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals.Origins of enhanced proton transport in the Y7F mutant of human carbonic anhydrase II.Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding.Preliminary joint neutron and X-ray crystallographic study of human carbonic anhydrase II.Elucidation of the proton transport mechanism in human carbonic anhydrase II.Sequestration of carbon dioxide by the hydrophobic pocket of the carbonic anhydrases.Update on carbonic anhydrase inhibitors: a patent review (2008 - 2011).A matter of structure: structural comparison of fungal carbonic anhydrases.Carbonic anhydrase inhibitors: a review on the progress of patent literature (2011-2016).
P2860
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P2860
Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Atomic crystal and molecular d ...... the proton transfer mechanism
@ast
Atomic crystal and molecular d ...... the proton transfer mechanism
@en
Atomic crystal and molecular d ...... the proton transfer mechanism
@nl
type
label
Atomic crystal and molecular d ...... the proton transfer mechanism
@ast
Atomic crystal and molecular d ...... the proton transfer mechanism
@en
Atomic crystal and molecular d ...... the proton transfer mechanism
@nl
prefLabel
Atomic crystal and molecular d ...... the proton transfer mechanism
@ast
Atomic crystal and molecular d ...... the proton transfer mechanism
@en
Atomic crystal and molecular d ...... the proton transfer mechanism
@nl
P2093
P50
P356
P1433
P1476
Atomic crystal and molecular d ...... the proton transfer mechanism
@en
P2093
C Mark Maupin
Chingkuang Tu
David N Silverman
Monika Budayova-Spano
S Zoë Fisher
P304
P356
10.1021/BI062066Y
P407
P577
2007-03-20T00:00:00Z