Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands - Wikidata - awgldk - TriplyDB

Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands

Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands

http://www.wikidata.org/entity/Q27644330

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Polyacetylenes from Notopterygium incisum--new selective partial agonists of peroxisome proliferator-activated receptor-gamma Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism Structural basis for the activation of PPARgamma by oxidized fatty acids The nuclear receptor PPARγ individually responds to serotonin- and fatty acid-metabolites Resveratrol and Its Metabolites Bind to PPARs Structural basis of the transactivation deficiency of the human PPARγ F360L mutant associated with familial partial lipodystrophy On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles Dietary α-eleostearic acid ameliorates experimental inflammatory bowel disease in mice by activating peroxisome proliferator-activated receptor-γ Identification of PPARgamma partial agonists of natural origin (I): development of a virtual screening procedure and in vitro validation A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability Virtual Screening as a Technique for PPAR Modulator Discovery.Pharmacophore-driven identification of PPARγ agonists from natural sources.Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis.The novel PPAR α/γ dual agonist MHY 966 modulates UVB-induced skin inflammation by inhibiting NF-κB activity.Pharmacophore modeling improves virtual screening for novel peroxisome proliferator-activated receptor-gamma ligands.Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex.N-Acetylfarnesylcysteine is a novel class of peroxisome proliferator-activated receptor γ ligand with partial and full agonist activity in vitro and in vivo.Mechanisms of peroxisome proliferator activated receptor γ regulation by non-steroidal anti-inflammatory drugs.Allosteric Pathways in the PPARγ-RXRα nuclear receptor complex.Lysophospholipid interactions with protein targets.Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro.Single-Nucleotide Polymorphism of PPARγ, a Protein at the Crossroads of Physiological and Pathological Processes.Identifying and characterizing promiscuous targets: implications for virtual screening.Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode.Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin.Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor.Bacterial expression, refolding, functional characterization, and mass spectrometric identification of full-length human PPAR-gamma.Ginsenoside Rg3 stereoisomers differentially inhibit vascular smooth muscle cell proliferation and migration in diabetic atherosclerosis.A structural mechanism for directing corepressor-selective inverse agonism of PPARγ Signaling Mechanisms of Selective PPAR Modulators in Alzheimer's Disease SAR and Computer-Aided Drug Design Approaches in the Discovery of Peroxisome Proliferator-Activated ReceptorγActivators: A Perspective

P2860

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P2860

Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands

http://www.wikidata.org/entity/Q27644330

description

2007 nî lūn-bûn

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2007 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2007 թվականի հունիսին հրատարակված գիտական հոդված

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2007年の論文

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Andrea Galmozzi

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Cristina Godio

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Donatella Caruso

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Fernando Mazza

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Fulvio Loiodice

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Giorgio Pochetti

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Paolo Tortorella

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Samuele Scurati

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P2860

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Processing of X-ray diffraction data collected in oscillation mode

A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation

Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors

Crystal structure of a mutant hERalpha ligand-binding domain reveals key structural features for the mechanism of partial agonism

Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12

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17314-24

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884156

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10.1074/JBC.M702316200

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23

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282

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Ettore Novellino

Antonio Laghezza

Antonio Lavecchia

Maurizio Crestani

Giuseppe Fracchiolla

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2007-06-08T00:00:00Z

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17403688

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crystal structure