Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutan

Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutan

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http://www.wikidata.org/entity/Q27644408
Update on recent preclinical and clinical studies of T790M mutant-specific irreversible epidermal growth factor receptor tyrosine kinase inhibitorsSpecificity of Protein Covalent Modification by the Electrophilic Proteasome Inhibitor Carfilzomib in Human CellsCovalent EGFR Inhibitors: Binding Mechanisms, Synthetic Approaches, and Clinical Profiles.Recent Development of the Second and Third Generation Irreversible Epidermal Growth Factor Receptor Inhibitors.Non-kinase targets of protein kinase inhibitors.Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation.Molecular Skin Surface-Based Transformation Visualization between Biological Macromolecules.Pockets as structural descriptors of EGFR kinase conformations.Design, synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase.Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors.
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Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutan

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http://www.wikidata.org/entity/Q27644408
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2016 nî lūn-bûn
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2016 թուականի Մարտին հրատարակուած գիտական յօդուած
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2016 թվականի մարտին հրատարակված գիտական հոդված
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2016年の論文
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2016年學術文章
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name
Discovery of 1-{(3R,4R)-3-[({5 ...... of T790M-Containing EGFR Mutan
@nl
type
label
Discovery of 1-{(3R,4R)-3-[({5 ...... of T790M-Containing EGFR Mutan
@nl
prefLabel
Discovery of 1-{(3R,4R)-3-[({5 ...... of T790M-Containing EGFR Mutan
@nl
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Discovery of 1-{(3R,4R)-3-[({5 ...... T790M-Containing EGFR Mutants
@en
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10.1021/ACS.JMEDCHEM.5B01633
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