Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance
about
Resistance to antibiotics targeted to the bacterial cell wallBiochemical Characterization and Crystal Structures of a Fungal Family 3 -Glucosidase, Cel3A from Hypocrea jecorinaInsight into a strategy for attenuating AmpC-mediated β-lactam resistance: Structural basis for selective inhibition of the glycoside hydrolase NagZScreening-based discovery of drug-likeO-GlcNAcase inhibitor scaffoldsRole of a PA14 domain in determining substrate specificity of a glycoside hydrolase family 3 β-glucosidase from Kluyveromyces marxianusStructural and Kinetic Analysis of Bacillus subtilis N-Acetylglucosaminidase Reveals a Unique Asp-His Dyad MechanismInhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 AdipocytesActive-pocket size differentiating insectile from bacterial chitinolytic β-N-acetyl-D-hexosaminidasesStructure and activity of exo-1,3/1,4-β-glucanase from marine bacterium Pseudoalteromonas sp. BB1 showing a novel C-terminal domainGaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approachThe Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to β-LactamsCrystal structures of glycoside hydrolase family 3 β-glucosidase 1 from Aspergillus aculeatusSelective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactamsThe structure of hyperthermophilic β-N-acetylglucosaminidase reveals a novel dimer architecture associated with the active siteGaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysisHost-guest chemistry of the peptidoglycanThe sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa.Distinct roles of major peptidoglycan recycling enzymes in β-Lactamase production in Shewanella oneidensisOvercoming resistance to β-lactam antibiotics.AmpG inactivation restores susceptibility of pan-beta-lactam-resistant Pseudomonas aeruginosa clinical strains.Crystallization and preliminary X-ray crystallographic analysis of the β-N-acetylglucosaminidase CbsA from Thermotoga neapolitanaNagZ-dependent and NagZ-independent mechanisms for β-lactamase expression in Stenotrophomonas maltophiliaMessenger functions of the bacterial cell wall-derived muropeptides.Inhibitors for Bacterial Cell-Wall Recycling.A unique GCN5-related glucosamine N-acetyltransferase region exist in the fungal multi-domain glycoside hydrolase family 3 β-N-acetylglucosaminidaseBacterial peptidoglycan (murein) hydrolases.How bacteria consume their own exoskeletons (turnover and recycling of cell wall peptidoglycan)Providing β-lactams a helping hand: targeting the AmpC β-lactamase induction pathway.Bacterial cell-wall recycling.Pseudomonas aeruginosa: targeting cell-wall metabolism for new antibacterial discovery and development.Synergistic activity of fosfomycin, β-lactams and peptidoglycan recycling inhibition against Pseudomonas aeruginosa.Beta-lactamase induction and cell wall metabolism in Gram-negative bacteria.NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosaInactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa.Diversity and regulation of intrinsic β-lactamases from non-fermenting and other Gram-negative opportunistic pathogens.Antimicrobial Nanomaterials: Why Evolution Matters.Crystal structure of native β-N-acetylhexosaminidase isolated from Aspergillus oryzae sheds light onto its substrate specificity, high stability, and regulation by propeptide.Diamide Inhibitors of the Bacillus subtilis N-Acetylglucosaminidase LytG That Exhibit Antibacterial Activity.Application of Nanoparticle Technology to Reduce the Anti-Microbial Resistance through β-Lactam Antibiotic-Polymer Inclusion Nano-Complex.Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance.
P2860
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P2860
Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance
description
2007 nî lūn-bûn
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2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
Small molecule inhibitors of a ...... ediated beta-lactam resistance
@ast
Small molecule inhibitors of a ...... ediated beta-lactam resistance
@en
Small molecule inhibitors of a ...... ediated beta-lactam resistance
@nl
type
label
Small molecule inhibitors of a ...... ediated beta-lactam resistance
@ast
Small molecule inhibitors of a ...... ediated beta-lactam resistance
@en
Small molecule inhibitors of a ...... ediated beta-lactam resistance
@nl
prefLabel
Small molecule inhibitors of a ...... ediated beta-lactam resistance
@ast
Small molecule inhibitors of a ...... ediated beta-lactam resistance
@en
Small molecule inhibitors of a ...... ediated beta-lactam resistance
@nl
P2093
P2860
P356
P1476
Small molecule inhibitors of a ...... ediated beta-lactam resistance
@en
P2093
Brian L Mark
David J Vocadlo
Keith A Stubbs
Misty Balcewich
P2860
P304
P356
10.1074/JBC.M700084200
P407
P577
2007-07-20T00:00:00Z