Structure of the catalytic domain of human polo-like kinase 1
about
PLK-1 Targeted Inhibitors and Their Potential against TumorigenesisPolo-like kinase 1, on the rise from cell cycle regulation to prostate cancer developmentStructure of theBrachydanio rerioPolo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzymeAminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural CharacterizationSelective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brainStructural basis for the inhibition of Polo-like kinase 1Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entryMapping the conformational transition in Src activation by cumulating the information from multiple molecular dynamics trajectoriesUse of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis.Phosphorylation of synucleins by members of the Polo-like kinase family.Reaction-driven de novo design, synthesis and testing of potential type II kinase inhibitors.Plk1-targeted small molecule inhibitors: molecular basis for their potency and specificity.Polo-like kinase-activating kinases: Aurora A, Aurora B and what else?Glioma-propagating cells as an in vitro screening platform: PLK1 as a case study.Cdk1 plays matchmaker for the Polo-like kinase and its activator SPAT-1/Bora.Validation of Polo-like kinase 1 as a therapeutic target in pancreatic cancer cellsTrypanosoma brucei Polo-like kinase is essential for basal body duplication, kDNA segregation and cytokinesisRecent Advances and New Strategies in Targeting Plk1 for Anticancer TherapyA coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration.JNK-associated Leucine Zipper Protein Functions as a Docking Platform for Polo-like Kinase 1 and Regulation of the Associating Transcription Factor Forkhead Box Protein K1.Ligand discovery and virtual screening using the program LIDAEUS.Centrosomal MPF triggers the mitotic and morphogenetic switches of fission yeastLaterally mobile, functionalized self-assembled monolayers at the fluorous-aqueous interface in a plug-based microfluidic system: characterization and testing with membrane protein crystallization.Polo-like kinase 1 inhibitors in mono- and combination therapies: a new strategy for treating malignancies.Volasertib for the treatment of acute myeloid leukemia: a review of preclinical and clinical development.Polo-like kinases: structural variations lead to multiple functions.Understanding the Polo Kinase machine.The hunt for antimitotic agents: an overview of structure-based design strategies.Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family membersIdentification of green tea catechins as potent inhibitors of the polo-box domain of polo-like kinase 1.Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1.Dissecting the phenotypes of Plk1 inhibition in cancer cells using novel kinase inhibitory chemical CBB2001.Identification of novel polo-like kinase 1 inhibitors by a hybrid virtual screening.An efficient platform for screening expression and crystallization of glycoproteins produced in human cells.Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding.Computational design of targeted inhibitors of polo-like kinase 1 (plk1).Drugs by numbers: reaction-driven de novo design of potent and selective anticancer leads.Discovery of Non-ATP-Competitive Inhibitors of Polo-like Kinase 1.Linear Regression QSAR Models for Polo-Like Kinase-1 Inhibitors.The multifaceted allosteric regulation of Aurora kinase A.
P2860
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P2860
Structure of the catalytic domain of human polo-like kinase 1
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structure of the catalytic domain of human polo-like kinase 1
@ast
Structure of the catalytic domain of human polo-like kinase 1
@en
Structure of the catalytic domain of human polo-like kinase 1
@nl
type
label
Structure of the catalytic domain of human polo-like kinase 1
@ast
Structure of the catalytic domain of human polo-like kinase 1
@en
Structure of the catalytic domain of human polo-like kinase 1
@nl
prefLabel
Structure of the catalytic domain of human polo-like kinase 1
@ast
Structure of the catalytic domain of human polo-like kinase 1
@en
Structure of the catalytic domain of human polo-like kinase 1
@nl
P2093
P356
P1433
P1476
Structure of the catalytic domain of human polo-like kinase 1
@en
P2093
Alan C Cheng
Alissa L Sheils
Christine Loh
Cristina Lewis
Cyrille Kuhn
Darcy Kohls
Jim Nonomiya
Kimberly A Verdries
Michael Kothe
Rocco Coli
P304
P356
10.1021/BI602474J
P407
P577
2007-05-22T00:00:00Z