Exploitation of structural and regulatory diversity in glutamate racemases
about
Dynamic dissociating homo-oligomers and the control of protein functionSpecificity Determinants for Lysine Incorporation in Staphylococcus aureus Peptidoglycan as Revealed by the Structure of a MurE Enzyme Ternary ComplexAsymmetric deactivation of HIV-1 gp41 following fusion inhibitor bindingBiochemical Characterization of Glutamate Racemase-A New Candidate Drug Target against Burkholderia cenocepacia InfectionsDeterminants of catalytic power and ligand binding in glutamate racemase.Equilibrium fluctuations of a single folded protein reveal a multitude of potential cryptic allosteric sites.Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery.Discovery of multiple hidden allosteric sites by combining Markov state models and experimentsPyridodiazepine amines are selective therapeutic agents for helicobacter pylori by suppressing growth through inhibition of glutamate racemase but are predicted to require continuous elevated levels in plasma to achieve clinical efficacyGlutamate Racemase Mutants of Bacillus anthracis.Exploring the chemistry and evolution of the isomerasesDetermination of antibiotic hypersensitivity among 4,000 single-gene-knockout mutants of Escherichia coliCytoplasmic steps of peptidoglycan biosynthesis.Nanorod-Shaped Basic Al2O3 Catalyzed N,N-Diformylation of Bisuracil Derivatives: A Greener "NOSE" Approach.Glutamate racemase dimerization inhibits dynamic conformational flexibility and reduces catalytic rates.Novel Helicobacter pylori therapeutic targets: the unusual suspects.Glutamate racemase as a target for drug discovery.Viable screening targets related to the bacterial cell wall.Nontraditional therapies to treat Helicobacter pylori infection.Glutamate Racemase Is the Primary Target of β-Chloro-d-Alanine in Mycobacterium tuberculosis.Exploiting racemases.Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.Resistance mechanism to an uncompetitive inhibitor of a single-substrate, single-product enzyme: a study of Helicobacter pylori glutamate racemase.Evaluation of new antimicrobial agents on Bacillus spp. strains: docking affinity and in vitro inhibition of glutamate-racemase.Nature of allosteric inhibition in glutamate racemase: discovery and characterization of a cryptic inhibitory pocket using atomistic MD simulations and pKa calculations.In silico optimization of a fragment-based hit yields biologically active, high-efficiency inhibitors for glutamate racemase.A comparative modeling and molecular docking study on Mycobacterium tuberculosis targets involved in peptidoglycan biosynthesis.Pivotal Enzyme in Glutamate Metabolism of Poly-g-Glutamate-Producing Microbes.Exploiting Enzyme Plasticity in Virtual Screening: High Efficiency Inhibitors of Glutamate Racemase.Enzymatic enantioselective decarboxylative protonation of heteroaryl malonates.Flooding enzymes: quantifying the contributions of interstitial water and cavity shape to ligand binding using extended linear response free energy calculations.Hybrid Steered Molecular Dynamics-Docking: An Efficient Solution to the Problem of Ranking Inhibitor Affinities Against a Flexible Drug Target.Pyrazolopyrimidinediones are selective agents for Helicobacter pylori that suppress growth through inhibition of glutamate racemase (MurI).Biosynthesis of a Novel Glutamate Racemase Containing a Site-Specific 7-Hydroxycoumarin Amino Acid: Enzyme-Ligand Promiscuity Revealed at the Atomistic Level.Study on variability assessment and evolutionary relationships of glutamate racemase in Pseudomonas species.Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis.Primordial-like enzymes from bacteria with reduced genomes.A Synthesis of Exiguaquinol Dessulfate.Substituent Effects on Carbon Acidity in Aqueous Solution and at Enzyme Active Sites.Overexpression of a newly identified d-amino acid transaminase in Mycobacterium smegmatis complements glutamate racemase deletion.
P2860
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P2860
Exploitation of structural and regulatory diversity in glutamate racemases
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Exploitation of structural and regulatory diversity in glutamate racemases
@ast
Exploitation of structural and regulatory diversity in glutamate racemases
@en
Exploitation of structural and regulatory diversity in glutamate racemases
@nl
type
label
Exploitation of structural and regulatory diversity in glutamate racemases
@ast
Exploitation of structural and regulatory diversity in glutamate racemases
@en
Exploitation of structural and regulatory diversity in glutamate racemases
@nl
prefLabel
Exploitation of structural and regulatory diversity in glutamate racemases
@ast
Exploitation of structural and regulatory diversity in glutamate racemases
@en
Exploitation of structural and regulatory diversity in glutamate racemases
@nl
P2093
P3181
P356
P1433
P1476
Exploitation of structural and regulatory diversity in glutamate racemases
@en
P2093
Boudewijn L M de Jonge
D Trevor Newton
Gunther Kern
Richard A Alm
Rutger H A Folmer
Stewart L Fisher
Thomas A Keating
Tomas Lundqvist
Yafeng Xue
P2860
P2888
P304
P3181
P356
10.1038/NATURE05689
P407
P577
2007-06-14T00:00:00Z
P5875
P6179
1034281016