A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins
about
Disruption of the integrin alphaLbeta2 transmembrane domain interface by beta2 Thr-686 mutation activates alphaLbeta2 and promotes micro-clustering of the alphaL subunitsThe structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signallingMolecular dynamics simulations of forced unbending of integrin α(v)β₃Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied ForcesStructure of an integrin with an αI domain, complement receptor type 4Protein stability: a crystallographer's perspectiveFocal adhesions are sites of integrin extension.Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach.Integrin inside-out signaling and the immunological synapseMetal ion and ligand binding of integrin α5β1Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopyRegulation of integrin affinity on cell surfacesThe Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological LigandThree-Dimensional Structures of Full-Length, Membrane-Embedded Human α(IIb)β(3) Integrin ComplexesLeukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops.Linking integrin conformation to function.Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen.The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties.Conformational equilibria and intrinsic affinities define integrin activation.Affinity, lateral mobility, and clustering contribute independently to beta 2-integrin-mediated adhesion.The novel S527F mutation in the integrin beta3 chain induces a high affinity alphaIIbbeta3 receptor by hindering adoption of the bent conformation.Solution properties of full-length integrin alpha(IIb)beta3 refined models suggest environment-dependent induction of alternative bent /extended resting states.Urokinase-type plasminogen activator receptor induces conformational changes in the integrin alphaMbeta2 headpiece and reorientation of its transmembrane domains.The human platelet antigen-1b variant of αIIbβ3 allosterically shifts the dynamic conformational equilibrium of this integrin toward the active state.
P2860
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P2860
A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
A structural hypothesis for th ...... the leukocyte beta2 integrins
@ast
A structural hypothesis for th ...... the leukocyte beta2 integrins
@en
A structural hypothesis for th ...... the leukocyte beta2 integrins
@nl
type
label
A structural hypothesis for th ...... the leukocyte beta2 integrins
@ast
A structural hypothesis for th ...... the leukocyte beta2 integrins
@en
A structural hypothesis for th ...... the leukocyte beta2 integrins
@nl
prefLabel
A structural hypothesis for th ...... the leukocyte beta2 integrins
@ast
A structural hypothesis for th ...... the leukocyte beta2 integrins
@en
A structural hypothesis for th ...... the leukocyte beta2 integrins
@nl
P2093
P2860
P356
P1476
A structural hypothesis for th ...... the leukocyte beta2 integrins
@en
P2093
Edward P Mitchell
Minlong Shi
S K Alex Law
Shen Yun Foo
Suet-Mien Tan
P2860
P304
P356
10.1074/JBC.M701670200
P407
P577
2007-10-12T00:00:00Z