Crystal structure of E47-NeuroD1/beta2 bHLH domain-DNA complex: heterodimer selectivity and DNA recognition
about
Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibitionIntermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNACrystal Structure of the Minimalist Max-E47 Protein ChimeraStructural Basis for LMO2-Driven Recruitment of the SCL:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional TargetsConformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complexThe basic helix-loop-helix region of the transcriptional repressor hairy and enhancer of split 1 is preorganized to bind DNAThe role of response elements organization in transcription factor selectivity: the IFN-β enhanceosome exampleNeuroD1 is required for survival of photoreceptors but not pinealocytes: results from targeted gene deletion studies.Cloning, purification and preliminary X-ray data analysis of the human ID2 homodimerMultiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastomaDestabilization of the TWIST1/E12 complex dimerization following the R154P point-mutation of TWIST1: an in silico approach.Otx-dependent expression of proneural bHLH genes establishes a neuronal bilateral asymmetry in C. elegans.Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis.Re-visiting protein-centric two-tier classification of existing DNA-protein complexes.Computational modeling of the bHLH domain of the transcription factor TWIST1 and R118C, S144R and K145E mutantsRecurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing.Using a structural and logics systems approach to infer bHLH-DNA binding specificity determinants.Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2.Essential C-terminal region of the baculovirus minor capsid protein VP80 binds DNAGenome-wide target analysis of NEUROD2 provides new insights into regulation of cortical projection neuron migration and differentiationATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreousA direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressorsMutations in TCF12, encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosis.Deciphering the molecular mechanisms underlying the binding of the TWIST1/E12 complex to regulatory E-box sequences.Interhelical loops within the bHLH domain are determinant in maintaining TWIST1-DNA complexes.Retinoic acid signaling and neuronal differentiation.Inhibitor of differentiation 4 (ID4) acts as an inhibitor of ID-1, -2 and -3 and promotes basic helix loop helix (bHLH) E47 DNA binding and transcriptional activity.Pitt-Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects.Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming.Determinants of the DNA binding specificity of class I and class II TCP transcription factors.Expression and cellular localization of the transcription factor NeuroD1 in the developing and adult rat pineal gland.Conversion of MyoD to a neurogenic factor: binding site specificity determines lineage.INDEHISCENT and SPATULA interact to specify carpel and valve margin tissue and thus promote seed dispersal in Arabidopsis.Novel small molecule inhibitors of the OLIG2 transcription factor: promising new therapeutics for glioblastoma.The Repression of Atoh1 by Neurogenin1 during Inner Ear Development.New structural determinants for c-Myc specific heterodimerization with Max and development of a novel homodimeric c-Myc b-HLH-LZ.Functional analysis of TCF4 missense mutations that cause Pitt-Hopkins syndrome.Intrinsic DNA binding properties demonstrated for lineage-specifying basic helix-loop-helix transcription factors.
P2860
Q24310008-FB45B643-AF66-4C58-B473-B833462FA876Q27675440-04D007E0-E713-4462-9AE9-15C1A382F120Q27677836-107F4F6D-A182-4278-BBD6-F6B10E593F3CQ27678941-A2148DD0-A363-46F7-90B9-A089F6CA1A48Q27681258-F6C19DFF-8152-42AF-AF41-ED42A8250301Q27688110-7B9F911A-E9B8-4B4E-A48B-E52AE358A973Q28478618-46F8E49B-267B-4CDE-8F04-A11ACA71A5D6Q30524896-08AA27C5-1C70-4CDF-A507-0D1AAF3F3DD1Q30577127-9DB17507-1963-44AD-A631-206DA817B006Q33618337-C20259AB-5A60-4FEE-B13E-4D536BCE1C48Q33706887-14FA6AD5-85E3-44DE-80C7-DD51719114F4Q34290559-8656452A-AC21-470F-9F8F-9556AF9EC1DFQ34329197-334D30E2-13DF-479E-ADA5-F3E1F789DF75Q34338657-F486DAA7-0797-4DED-A2FA-F3B2CF6E3830Q34354239-13F5F97E-59BF-44EB-AEA9-1861E19CD45BQ34473466-A94C4B6D-531D-478B-9F0D-14A02515C6A3Q35040989-4AFEB13C-373E-4D10-8123-68E4AEA342FBQ35397840-A57A7A8A-FEC2-4563-A019-9A49BB9D7DDCQ35689604-40420FE2-E1A0-4BE9-B710-6B67E67A1D22Q35765049-BBB27B14-2246-40A4-BFDB-F1D170225139Q36122441-284A80AE-6A7A-4376-A66E-EA4FB7FC6CD9Q36245078-9487831F-92A4-4B2C-A40A-C73A0840385AQ36824880-CE6D911E-FB98-455D-9AB2-819074794784Q37021574-F2813BC4-D6C8-4845-B1E5-FCC5B8C850C3Q37405800-B90F43DA-EAF0-4C18-890B-111DFCACFFF8Q38307264-D0D63717-76B0-4C3B-9F5D-B39F28AD5E95Q38898841-B93D6DDE-0262-40A9-B93F-810F1E9F896FQ39372163-CDC182C4-AD8C-41FB-852F-BA22CDE89EDEQ39960559-A5093E73-16D4-4DB8-8E9E-37B5FAC265E5Q40082272-BCF68994-217F-47FC-93A5-0FFAD9E6DD05Q41264851-7F64078D-91D7-4EE3-A50C-562760A57A46Q42100429-D6C0B9DA-0452-4A15-93B4-1911BFD57ADCQ42619862-E82FD121-86A3-4F45-8BF4-1AE101DFE845Q44066325-666187BE-AC5A-464D-A52A-355BD8B10B27Q44121463-9A936FDF-06CD-4FD9-96B7-B015898F2330Q44268985-BF32E436-BBE6-4A46-B1CD-B1A479661DDCQ45036364-CECDA524-51C6-4964-87BB-813654A40F65Q52368938-A8963842-A66B-4858-9CE4-08BB786EB82B
P2860
Crystal structure of E47-NeuroD1/beta2 bHLH domain-DNA complex: heterodimer selectivity and DNA recognition
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Crystal structure of E47-Neuro ...... electivity and DNA recognition
@ast
Crystal structure of E47-Neuro ...... electivity and DNA recognition
@en
Crystal structure of E47-Neuro ...... electivity and DNA recognition
@nl
type
label
Crystal structure of E47-Neuro ...... electivity and DNA recognition
@ast
Crystal structure of E47-Neuro ...... electivity and DNA recognition
@en
Crystal structure of E47-Neuro ...... electivity and DNA recognition
@nl
prefLabel
Crystal structure of E47-Neuro ...... electivity and DNA recognition
@ast
Crystal structure of E47-Neuro ...... electivity and DNA recognition
@en
Crystal structure of E47-Neuro ...... electivity and DNA recognition
@nl
P2093
P3181
P356
P1433
P1476
Crystal structure of E47-Neuro ...... electivity and DNA recognition
@en
P2093
Antonella Longo
Gerald P Guanga
Robert B Rose
P304
P3181
P356
10.1021/BI701527R
P407
P577
2008-01-08T00:00:00Z