Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73
about
Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motifThe structure and interactions of the proline-rich domain of ASPP2Structural Basis for ASPP2 Recognition by the Tumor Suppressor p73The ASPP interaction network: electrostatic differentiation between pro- and anti-apoptotic proteinsp73 as a pharmaceutical target for cancer therapyHighly homologous proteins exert opposite biological activities by using different interaction interfacesRegulation of ASPP2 interaction with p53 core domain by an intramolecular autoinhibitory mechanism.Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins.DNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions.TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.iASPP is over-expressed in human non-small cell lung cancer and regulates the proliferation of lung cancer cells through a p53 associated pathway.TAp63 induces senescence and suppresses tumorigenesis in vivo.In vitro effect of iASPP on cell growth of oral tongue squamous cell carcinoma.iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia.Expression pattern of the apoptosis-stimulating protein of p53 family in p53+ human breast cancer cell lines.Waved with open eyelids 2 (woe2) is a novel spontaneous mouse mutation in the protein phosphatase 1, regulatory (inhibitor) subunit 13 like (Ppp1r13l) gene.Attenuated expression of apoptosis stimulating protein of p53-2 (ASPP2) in human acute leukemia is associated with therapy failurep73 in Cancer.Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification.Pathway Regulation of p63, a Director of Epithelial Cell FateTherapeutic prospects for p73 and p63: rising from the shadow of p53.p53-family proteins and their regulators: hubs and spokes in tumor suppression.Restoring p53 tumor suppressor activity as an anticancer therapeutic strategy.Mechanisms regulating epidermal stem cells.The TP73 complex network: ready for clinical translation in cancer?iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes.Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.Insight into the structural basis of pro- and antiapoptotic p53 modulation by ASPP proteins.A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity.iASPP facilitates tumor growth by promoting mTOR-dependent autophagy in human non-small-cell lung cancer.Epigenetic silencing of ASPP1 confers 5-FU resistance in clear cell renal cell carcinoma by preventing p53 activation.TP53 binds PPP1R13LTP53 family members bind PPP1R13B or TP53BP2Mild Therapeutic Hypothermia Protects the Brain from Ischemia/Reperfusion Injury through Upregulation of iASPP.
P2860
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P2860
Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Biochemical and structural stu ...... l binding to p53, p63, and p73
@ast
Biochemical and structural stu ...... l binding to p53, p63, and p73
@en
Biochemical and structural stu ...... l binding to p53, p63, and p73
@nl
type
label
Biochemical and structural stu ...... l binding to p53, p63, and p73
@ast
Biochemical and structural stu ...... l binding to p53, p63, and p73
@en
Biochemical and structural stu ...... l binding to p53, p63, and p73
@nl
prefLabel
Biochemical and structural stu ...... l binding to p53, p63, and p73
@ast
Biochemical and structural stu ...... l binding to p53, p63, and p73
@en
Biochemical and structural stu ...... l binding to p53, p63, and p73
@nl
P921
P3181
P1433
P1476
Biochemical and structural stu ...... l binding to p53, p63, and p73
@en
P2093
Ross Alexander Robinson
P304
P3181
P356
10.1016/J.STR.2007.11.012
P577
2008-02-01T00:00:00Z