Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
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The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine PhosphorylaseThe structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologsStructure of the putative dihydroorotate dehydrogenase fromStreptococcus mutansThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsAllosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralogPyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream formsLeflunomide reduces proliferation and induces apoptosis in neuroblastoma cells in vitro and in vivoPyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma bruceiThe Open Form Inducer Approach for Structure-Based Drug Design.Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.An essential farnesylated kinesin in Trypanosoma brucei.Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3.Genetic dissection of pyrimidine biosynthesis and salvage in Leishmania donovani.Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing ProteinsGMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.Evaluation of Antigens for Development of a Serological Test for Human African TrypanosomiasisLessons from high-throughput protein crystallization screening: 10 years of practical experience.Product feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozymeSubstrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of Leishmania donovani pyrimidine auxotrophs.State of the art in African trypanosome drug discovery.Development of novel drugs for human African trypanosomiasis.Novel Diketopiperazine Dihydroorotate Dehydrogenase Inhibitors Purified from Traditional Tibetan Animal Medicine Osteon Myospalacem Baileyi.Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets.Recombinant production, crystallization and crystal structure determination of dihydroorotate dehydrogenase from Leishmania (Viannia) braziliensis.Insights into the mechanism of oxidation of dihydroorotate to orotate catalysed by human class 2 dihydroorotate dehydrogenase: a QM/MM free energy study.Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines.Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation.Disruption of the proton relay network in the class 2 dihydroorotate dehydrogenase from Escherichia coli.Roles in binding and chemistry for conserved active site residues in the class 2 dihydroorotate dehydrogenase from Escherichia coli.Computational study of the mechanism of half-reactions in class 1A dihydroorotate dehydrogenase from Trypanosoma cruzi.Fresh insights into the pyrimidine metabolism in the trypanosomatids.Crystal structures of FMN-bound and FMN-free forms of dihydroorotate dehydrogenase from Trypanosoma brucei.Dihydroorotate Dehydrogenase: Knockdown Inhibits Cell Growth and Proliferation via Inducing Cell Cycle ArrestCurrent and Future Strategies for Improving Drug Discovery EfficiencySelective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions
P2860
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P2860
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Characterization of Trypanosom ...... ural, kinetic and RNAi studies
@ast
Characterization of Trypanosom ...... ural, kinetic and RNAi studies
@en
Characterization of Trypanosom ...... ural, kinetic and RNAi studies
@nl
type
label
Characterization of Trypanosom ...... ural, kinetic and RNAi studies
@ast
Characterization of Trypanosom ...... ural, kinetic and RNAi studies
@en
Characterization of Trypanosom ...... ural, kinetic and RNAi studies
@nl
prefLabel
Characterization of Trypanosom ...... ural, kinetic and RNAi studies
@ast
Characterization of Trypanosom ...... ural, kinetic and RNAi studies
@en
Characterization of Trypanosom ...... ural, kinetic and RNAi studies
@nl
P2093
P2860
P3181
P1476
Characterization of Trypanosom ...... ural, kinetic and RNAi studies
@en
P2093
Christophe L M J Verlinde
Ethan A Merritt
Frederick S Buckner
George T Detitta
J Robert Gillespie
Joseph R Luft
Margaret A Phillips
Nicholas A Malmquist
Oleksandr Kalyuzhniy
Tracy L Arakaki
P2860
P3181
P356
10.1111/J.1365-2958.2008.06131.X
P407
P577
2008-04-01T00:00:00Z