Design of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONS
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Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonistsEnhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINSInsulin analog with additional disulfide bond has increased stability and preserved activityProtective hinge in insulin opens to enable its receptor engagementConformational dynamics of insulin.An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic designFrustration in biomoleculesInsulin analogs for the treatment of diabetes mellitus: therapeutic applications of protein engineering.Insulin fibrillation and protein design: topological resistance of single-chain analogs to thermal degradation with application to a pump reservoir.Single-chain insulins as receptor agonists.Insulin: a small protein with a long journey.The road to the first, fully active and more stable human insulin variant with an additional disulfide bond.Pursuit of a perfect insulin.Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability.Development of glucose-responsive 'smart' insulin systems.Nisin-inducible secretion of a biologically active single-chain insulin analog by Lactococcus lactis NZ9000.Secretory expression and surface display of a new and biologically active single-chain insulin (SCI-59) analog by lactic acid bacteria.Helicity of short E-R/K peptides.Glucose-responsive insulin by molecular and physical design.An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein.Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding.Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer.All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element.
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P2860
Design of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONS
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Design of an Active Ultrastabl ...... , AND THERAPEUTIC IMPLICATIONS
@ast
Design of an Active Ultrastabl ...... , AND THERAPEUTIC IMPLICATIONS
@en
Design of an Active Ultrastabl ...... , AND THERAPEUTIC IMPLICATIONS
@nl
type
label
Design of an Active Ultrastabl ...... , AND THERAPEUTIC IMPLICATIONS
@ast
Design of an Active Ultrastabl ...... , AND THERAPEUTIC IMPLICATIONS
@en
Design of an Active Ultrastabl ...... , AND THERAPEUTIC IMPLICATIONS
@nl
prefLabel
Design of an Active Ultrastabl ...... , AND THERAPEUTIC IMPLICATIONS
@ast
Design of an Active Ultrastabl ...... , AND THERAPEUTIC IMPLICATIONS
@en
Design of an Active Ultrastabl ...... , AND THERAPEUTIC IMPLICATIONS
@nl
P2093
P2860
P356
P1476
Design of an Active Ultrastabl ...... , AND THERAPEUTIC IMPLICATIONS
@en
P2093
Michael A Weiss
Nelson B Phillips
Qing-xin Hua
Satoe H Nakagawa
Shi-quan Hu
Wenhua Jia
P2860
P304
P356
10.1074/JBC.M800313200
P407
P577
2008-05-23T00:00:00Z