Molecular architecture of G o and the structural basis for RGS16-mediated deactivation
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Signal activation and inactivation by the Gα helical domain: a long-neglected partner in G protein signalingStructural diversity in the RGS domain and its interaction with heterotrimeric G protein -subunitsStructural Determinants of G-protein Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling ComplexStructural and Functional Analysis of the Regulator of G Protein Signaling 2-Gαq ComplexA P-loop Mutation in Gα Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal PathogenesisA Constitutively Active Gα Subunit Provides Insights into the Mechanism of G Protein ActivationA structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration.Different biochemical properties explain why two equivalent Gα subunit mutants cause unrelated diseasesRegulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions.Adaptive evolution of signaling partnersTherapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors.Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.Mode of interaction of the Gαo subunit of heterotrimeric G proteins with the GoLoco1 motif of Drosophila Pins is determined by guanine nucleotides.Crystallization and preliminary X-ray diffraction studies of Drosophila melanogaster Gαo-subunit of heterotrimeric G protein in complex with the RGS domain of CG5036The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets.Invited review: Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis.Genome-Wide Screen for Genes Involved in Caenorhabditis elegans Developmentally Timed Sleep.Weak conservation of structural features in the interfaces of homologous transient protein-protein complexes.Interaction of the muscarinic acetylcholine receptor M₂ subtype with G protein Gα(i/o) isotypes and Gβγ subunits as studied with the maltose-binding protein-M₂-Gα(i/o) fusion proteins expressed in Escherichia coli.RGS proteins maintain robustness of GPCR-GIRK coupling by selective stimulation of the G protein subunit Gαo.Tyrosine phosphorylation switching of a G protein substrate.
P2860
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P2860
Molecular architecture of G o and the structural basis for RGS16-mediated deactivation
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Molecular architecture of G o and the structural basis for RGS16-mediated deactivation
@ast
Molecular architecture of G o and the structural basis for RGS16-mediated deactivation
@en
Molecular architecture of G o and the structural basis for RGS16-mediated deactivation
@nl
type
label
Molecular architecture of G o and the structural basis for RGS16-mediated deactivation
@ast
Molecular architecture of G o and the structural basis for RGS16-mediated deactivation
@en
Molecular architecture of G o and the structural basis for RGS16-mediated deactivation
@nl
prefLabel
Molecular architecture of G o and the structural basis for RGS16-mediated deactivation
@ast
Molecular architecture of G o and the structural basis for RGS16-mediated deactivation
@en
Molecular architecture of G o and the structural basis for RGS16-mediated deactivation
@nl
P2093
P2860
P3181
P356
P1476
Molecular architecture of G o and the structural basis for RGS16-mediated deactivation
@en
P2093
Ching-Kang Chen
Kevin C Slep
Melvin I Simon
Michele A Kercher
Paul B Sigler
Thomas Wieland
P2860
P304
P3181
P356
10.1073/PNAS.0801569105
P407
P577
2008-04-29T00:00:00Z