Crystal structure and molecular dynamics simulation of ubiquitin-like domain of murine parkin
about
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65Autoregulation of Parkin activity through its ubiquitin-like domainRBR E3 ubiquitin ligases: new structures, new insights, new questionsA molecular explanation for the recessive nature of parkin-linked Parkinson’s diseaseStructure of parkin reveals mechanisms for ubiquitin ligase activationDissection of USP catalytic domains reveals five common insertion pointsPINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65Label free fragment screening using surface plasmon resonance as a tool for fragment finding - analyzing parkin, a difficult CNS targetThe E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13Interaction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity.Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation.Parkin, A Top Level Manager in the Cell's Sanitation Department.Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.Specificity and disease in the ubiquitin systemBinding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.Molecular dynamics simulations of human E3 ubiquitin ligase Parkin.Impact of autosomal recessive juvenile Parkinson's disease mutations on the structure and interactions of the parkin ubiquitin-like domain.
P2860
Q24292901-4A30A21D-2492-44F2-A415-9CA23FF36B10Q24307382-0E3730CE-7694-4FAB-8EE7-B9A285932D1CQ26828565-B697D5C8-7C9B-416C-AAFD-E15332E4A232Q27678628-D31B917E-22A1-47D3-A0AD-295CD5AD3273Q27684576-24B29642-1FC6-4A01-9446-F6B1EBBCC004Q28257711-A34CFDC5-381B-4937-9DF4-495D77EED02FQ29622844-845633EE-528E-49D1-BEFE-E6F692409D0AQ30452210-C1D55013-76B7-4C44-9846-F9AD45223F52Q35199357-9460B134-11EE-4F04-BFD1-29C6E456776AQ36489290-198AECC2-221E-4F19-A153-F0CF5E9FDE47Q37589985-0BAF73BD-0EC3-43B0-ABFC-B861CA2459B9Q37883939-7897506E-885A-45D7-B64D-A22FBFF41F94Q38576138-2E4C389C-61E1-4E55-BE7F-4782E77D96D3Q38728113-F6057DAF-640B-47F9-9804-79843DDBE75BQ42071947-BAB9A478-D4CA-476D-8A74-B71DEEEAEE98Q42679405-EE3442C3-C3A8-42A5-8CC0-6165172615AEQ42705124-0287D555-4DAE-4B72-840C-7A435950299D
P2860
Crystal structure and molecular dynamics simulation of ubiquitin-like domain of murine parkin
description
2008 nî lūn-bûn
@nan
2008 թուականին հրատարակուած գիտական յօդուած
@hyw
2008 թվականին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Crystal structure and molecula ...... n-like domain of murine parkin
@ast
Crystal structure and molecula ...... n-like domain of murine parkin
@en
Crystal structure and molecula ...... n-like domain of murine parkin
@nl
type
label
Crystal structure and molecula ...... n-like domain of murine parkin
@ast
Crystal structure and molecula ...... n-like domain of murine parkin
@en
Crystal structure and molecula ...... n-like domain of murine parkin
@nl
prefLabel
Crystal structure and molecula ...... n-like domain of murine parkin
@ast
Crystal structure and molecula ...... n-like domain of murine parkin
@en
Crystal structure and molecula ...... n-like domain of murine parkin
@nl
P2093
P1476
Crystal structure and molecula ...... n-like domain of murine parkin
@en
P2093
Akihito Yamano
Heisaburo Shindo
Hiroo Miyagawa
Koji Tomoo
Kunihiro Kitamura
Toshimasa Ishida
Yasuhiro Mukai
P304
P356
10.1016/J.BBAPAP.2008.04.009
P407
P577
2008-01-01T00:00:00Z