Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit
about
Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteriaMode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomesR chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistanceGenome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistanceQuantitative proteomic view associated with resistance to clinically important antibiotics in Gram-positive bacteria: a systematic reviewResistance to linezolid caused by modifications at its binding site on the ribosomeAntibiotics that target protein synthesisU2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:Structures of Triacetyloleandomycin and Mycalamide A Bind to the Large Ribosomal Subunit of Haloarcula marismortuiThe structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibioticsStructure of the E. coli ribosome-EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EMTargeting Antibiotic ResistanceRibosome. The structure of the human mitochondrial ribosomeApproaches to Validate and Manipulate RNA Targets with Small Molecules in CellsSmall molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intronDiscovery and analysis of 4H-pyridopyrimidines, a class of selective bacterial protein synthesis inhibitors.In vitro and in vivo activities of three oxazolidinones against nonreplicating Mycobacterium tuberculosis.Probing translation with small-molecule inhibitorsThe chemical biology of new drugs in the development for tuberculosis.Linezolid-dependent function and structure adaptation of ribosomes in a Staphylococcus epidermidis strain exhibiting linezolid dependence.Expression Profile of Markers of Apoptosis, Injury and Oxidative Stress in Human Lung Epithelium Cells-A5449 Receiving Chronic Exposure of Potential Anti-Tubercular Drug-trans-Cyclohexane-1, 4-Diamine Derivative-"9u".Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance.The evolving role of chemical synthesis in antibacterial drug discovery.Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.Linezolid for treatment of chronic extensively drug-resistant tuberculosis.The roles of RNA in the synthesis of protein.Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201AAttenuation-based dual-fluorescent-protein reporter for screening translation inhibitors.In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatmentSyntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels-Alder reaction.Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.Linezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis.The genetic environment of the cfr gene and the presence of other mechanisms account for the very high linezolid resistance of Staphylococcus epidermidis isolate 426-3147LLinezolid Surveillance Results for the United States (LEADER Surveillance Program 2014).Structural basis for cross-resistance to ribosomal PTC antibiotics.Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center.In Vitro and In Vivo Activities of a Bi-Aryl Oxazolidinone, RBx 11760, against Gram-Positive Bacteria.Substitution of ethambutol with linezolid during the intensive phase of treatment of pulmonary tuberculosis: study protocol for a prospective, multicenter, randomized, open-label, phase II trial.Antibacterial oxazolidinones: emerging structure-toxicity relationships.The nitroimidazooxazines (PA-824 and analogs): structure-activity relationship and mechanistic studies.
P2860
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P2860
Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Crystal structure of the oxazo ...... d to the 50S ribosomal subunit
@ast
Crystal structure of the oxazo ...... d to the 50S ribosomal subunit
@en
Crystal structure of the oxazo ...... d to the 50S ribosomal subunit
@nl
type
label
Crystal structure of the oxazo ...... d to the 50S ribosomal subunit
@ast
Crystal structure of the oxazo ...... d to the 50S ribosomal subunit
@en
Crystal structure of the oxazo ...... d to the 50S ribosomal subunit
@nl
prefLabel
Crystal structure of the oxazo ...... d to the 50S ribosomal subunit
@ast
Crystal structure of the oxazo ...... d to the 50S ribosomal subunit
@en
Crystal structure of the oxazo ...... d to the 50S ribosomal subunit
@nl
P2093
P3181
P356
P1476
Crystal structure of the oxazo ...... d to the 50S ribosomal subunit
@en
P2093
Deping Wang
Erin M Duffy
Francois J Franceschi
Joseph A Ippolito
Peter B Moore
Thomas A Steitz
Zoltan F Kanyo
P304
P3181
P356
10.1021/JM800379D
P407
P577
2008-06-26T00:00:00Z