Structural insight into pH-induced conformational changes within the native human transthyretin tetramer
about
Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitorsStructural Insights into the Role of Mutations in AmyloidogenesisIodine Atoms: A New Molecular Feature for the Design of Potent Transthyretin Fibrillogenesis InhibitorsStructural Alterations within Native Amyloidogenic Immunoglobulin Light ChainsAmyloidogenic Potential of Transthyretin Variants: INSIGHTS FROM STRUCTURAL AND COMPUTATIONAL ANALYSESNovel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural AnalysisA Substructure Combination Strategy To Create Potent and Selective Transthyretin Kinetic Stabilizers That Prevent Amyloidogenesis and CytotoxicityNovel Zn2+-binding Sites in Human Transthyretin: IMPLICATIONS FOR AMYLOIDOGENESIS AND RETINOL-BINDING PROTEIN RECOGNITIONInfluence of sequence changes and environment on intrinsically disordered proteins.Post-translational modifications induce significant yet not extreme changes to protein structure.Transthyretin variants with improved inhibition of β-amyloid aggregation.Characterization of the interaction of β-amyloid with transthyretin monomers and tetramers.An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis.A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein.Uncovering the Mechanism of Aggregation of Human Transthyretin.Identification of beta-amyloid-binding sites on transthyretin.Localized structural fluctuations promote amyloidogenic conformations in transthyretin.Inhibition of human transthyretin aggregation by non-steroidal anti-inflammatory compounds: a structural and thermodynamic analysisTransthyretin as both a sensor and a scavenger of β-amyloid oligomersThe transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug.Understanding Pre-Eclampsia Using Alzheimer's Etiology: An Intriguing Viewpoint.Considerably Unfolded Transthyretin Monomers Preceed and Exchange with Dynamically Structured Amyloid Protofibrils.Quaternary structure, aggregation and cytotoxicity of transthyretin.Protein folding, misfolding and aggregation: The importance of two-electron stabilizing interactions.The importance of a gatekeeper residue on the aggregation of transthyretin: implications for transthyretin-related amyloidosesHydrogen-bond network and pH sensitivity in human transthyretin.Structural studies of "aggregation-prone" peptide-analogues of teleostean egg chorion ZPB proteins.Diagnostic hallmarks and pitfalls in late-onset progressive transthyretin-related amyloid-neuropathy.Understanding and Ameliorating the TTR AmyloidosesTransthyretin is a metallopeptidase with an inducible active site
P2860
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P2860
Structural insight into pH-induced conformational changes within the native human transthyretin tetramer
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structural insight into pH-ind ...... e human transthyretin tetramer
@ast
Structural insight into pH-ind ...... e human transthyretin tetramer
@en
Structural insight into pH-ind ...... e human transthyretin tetramer
@nl
type
label
Structural insight into pH-ind ...... e human transthyretin tetramer
@ast
Structural insight into pH-ind ...... e human transthyretin tetramer
@en
Structural insight into pH-ind ...... e human transthyretin tetramer
@nl
prefLabel
Structural insight into pH-ind ...... e human transthyretin tetramer
@ast
Structural insight into pH-ind ...... e human transthyretin tetramer
@en
Structural insight into pH-ind ...... e human transthyretin tetramer
@nl
P2093
P1476
Structural insight into pH-ind ...... e human transthyretin tetramer
@en
P2093
James C Sacchettini
Nilofar N Mohamedmohaideen
Satheesh K Palaninathan
William C Snee
P304
P356
10.1016/J.JMB.2008.07.029
P407
P577
2008-10-24T00:00:00Z