Mechanistic and Structural Analysis of Aminoglycoside N -Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant † ‡ - Wikidata - awgldk - TriplyDB

Mechanistic and Structural Analysis of Aminoglycoside N -Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant † ‡

Mechanistic and Structural Analysis of Aminoglycoside N -Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant † ‡

http://www.wikidata.org/entity/Q27651667

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Plasmid-mediated quinolone resistance: a multifaceted threat Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT)Bacterial GCN5-Related N-Acetyltransferases: From Resistance to Regulation Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections Identification and characterization of a novel aac(6')-Iag associated with the blaIMP-1-integron in a multidrug-resistant Pseudomonas aeruginosa Comparing aminoglycoside binding sites in bacterial ribosomal RNA and aminoglycoside modifying enzymes.Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia revealed by crystallographic and small-angle X-ray scattering analysis.Aminoglycoside modifying enzymes.Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor Plasmid-mediated quinolone resistance.Inhibitors of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] identified by in silico molecular docking.Structural and molecular basis for resistance to aminoglycoside antibiotics by the adenylyltransferase ANT(2″)-Ia Susceptibility of vertilmicin to modifications by three types of recombinant aminoglycoside-modifying enzymes.Structural characterization of a Gcn5-related N-acetyltransferase from Staphylococcus aureus.Purification, crystallization and preliminary X-ray analysis of the aminoglycoside-6'-acetyltransferase AAC(6')-Im.Identification of an Inhibitor of the Aminoglycoside 6'-N-Acetyltransferase type Ib [AAC(6')-Ib] by Glide Molecular Docking Identification and characterization of inhibitors of the aminoglycoside resistance acetyltransferase Eis from Mycobacterium tuberculosis Mechanisms of drug resistance: quinolone resistance.Prevalence of qnr and aac(6')-Ib-cr Genes in Clinical Isolates of Klebsiella Pneumoniae from Imam Hussein Hospital in Tehran.Global fluoroquinolone resistance epidemiology and implictions for clinical use.Cosubstrate tolerance of the aminoglycoside resistance enzyme Eis from Mycobacterium tuberculosis Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes.Rise and dissemination of aminoglycoside resistance: the aac(6')-Ib paradigm.High incidence of plasmid-mediated quinolone resistance genes among ciprofloxacin-resistant clinical isolates of Enterobacteriaceae at a tertiary care hospital in Puducherry, India.Novel resistance functions uncovered using functional metagenomic investigations of resistance reservoirs Temporal appearance of plasmid-mediated quinolone resistance genes Comparative Study of Eis-like Enzymes from Pathogenic and Nonpathogenic Bacteria.Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase.Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance.Effects of altering aminoglycoside structures on bacterial resistance enzyme activities.Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6') acetyltransferase-ie/aminoglycoside (2'') phosphotransferase-ia reveals a rigid solution structure.Tobramycin Variants with Enhanced Ribosome-Targeting Activity Multiple keys for a single lock: the unusual structural plasticity of the nucleotidyltransferase (4')/kanamycin complex.Aminoglycoside resistance profile and structural architecture of the aminoglycoside acetyltransferase AAC(6')-Im.Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.Polymorphism of antibiotic-inactivating enzyme driven by ecology expands the environmental resistome.A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad.Plasticity of aminoglycoside binding to antibiotic kinase APH(2")-Ia.Aminoglycoside resistance in clinical Escherichia coli and Klebsiella pneumoniae isolates from Western Norway.Identification of Novel Protein Lysine Acetyltransferases in Escherichia coli

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Mechanistic and Structural Analysis of Aminoglycoside N -Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant † ‡

http://www.wikidata.org/entity/Q27651667

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2008 nî lūn-bûn

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Mechanistic and Structural Ana ...... tive AAC(6′)-Ib-cr Variant † ‡

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Mechanistic and Structural Ana ...... tive AAC(6′)-Ib-cr Variant † ‡

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Mechanistic and Structural Ana ...... tive AAC(6′)-Ib-cr Variant † ‡

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David C Hooper

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George A Jacoby

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John S Blanchard

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Matthew W Vetting

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Subray S Hegde

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P2860

Investigation of the roles of catalytic residues in serotonin N-acetyltransferase

Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance

Coot: model-building tools for molecular graphics

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models

Refinement of macromolecular structures by the maximum-likelihood method

Scaling and assessment of data quality

The integration of macromolecular diffraction data

Structure and functions of the GNAT superfamily of acetyltransferases

Overexpression and mechanistic analysis of chromosomally encoded aminoglycoside 2'-N-acetyltransferase (AAC(2')-Ic) from Mycobacterium tuberculosis

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9825-35

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10.1021/BI800664X

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37

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47

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