Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site
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Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing AntibodiesCrystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design ImplicationsStructural Characterization of HIV gp41 with the Membrane-proximal External RegionStructure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1Elicitation of structure-specific antibodies by epitope scaffoldsBroad and potent neutralization of HIV-1 by a gp41-specific human antibodyStructure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing EpitopeDisruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41Crystal Structure of a Soluble Cleaved HIV-1 Envelope TrimerStructural Basis for HIV-1 Neutralization by 2F5-Like Antibodies m66 and m66.6Structure and Immunogenicity of a Peptide Vaccine, Including the Complete HIV-1 gp41 2F5 EpitopeRecognition of membrane-bound fusion-peptide/MPER complexes by the HIV-1 neutralizing 2F5 antibody: implications for anti-2F5 immunogenicityMax Bergmann lecture protein epitope mimetics in the age of structural vaccinologyBispecific engineered antibody domains (nanoantibodies) that interact noncompetitively with an HIV-1 neutralizing epitope and FcRn.Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions.Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining regionThe three lives of viral fusion peptidesHeterologous epitope-scaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant.Scaffolding to build a rational vaccine design strategy.Evaluation of the potency of the anti-idiotypic antibody Ab2/3H6 mimicking gp41 as an HIV-1 vaccine in a rabbit prime/boost studyIdentification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodiesStructure-guided alterations of the gp41-directed HIV-1 broadly neutralizing antibody 2F5 reveal new properties regarding its neutralizing function.Thermodynamic analysis of the binding of 2F5 (Fab and immunoglobulin G forms) to its gp41 epitope reveals a strong influence of the immunoglobulin Fc region on affinity.A fusion intermediate gp41 immunogen elicits neutralizing antibodies to HIV-1The stem of vesicular stomatitis virus G can be replaced with the HIV-1 Env membrane-proximal external region without loss of G function or membrane-proximal external region antigenic properties.Insights into vaccine development for acquired immune deficiency syndrome from crystal structures of human immunodeficiency virus-1 gp41 and equine infectious anemia virus gp45.Structure-based vaccine design in HIV: blind men and the elephant?Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies.Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5.Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralizationImmunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein.Binding of anti-membrane-proximal gp41 monoclonal antibodies to CD4-liganded and -unliganded human immunodeficiency virus type 1 and simian immunodeficiency virus virionsNeutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 are influenced by the transmembrane domain and the plasma membrane.Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10.Modulating immunogenic properties of HIV-1 gp41 membrane-proximal external region by destabilizing six-helix bundle structure.Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interfaceMolecular Mechanism and Energy Basis of Conformational Diversity of Antibody SPE7 Revealed by Molecular Dynamics Simulation and Principal Component Analysis
P2860
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P2860
Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structural details of HIV-1 re ...... bility, and anion-binding site
@ast
Structural details of HIV-1 re ...... bility, and anion-binding site
@en
Structural details of HIV-1 re ...... bility, and anion-binding site
@nl
type
label
Structural details of HIV-1 re ...... bility, and anion-binding site
@ast
Structural details of HIV-1 re ...... bility, and anion-binding site
@en
Structural details of HIV-1 re ...... bility, and anion-binding site
@nl
prefLabel
Structural details of HIV-1 re ...... bility, and anion-binding site
@ast
Structural details of HIV-1 re ...... bility, and anion-binding site
@en
Structural details of HIV-1 re ...... bility, and anion-binding site
@nl
P3181
P1476
Structural details of HIV-1 re ...... bility, and anion-binding site
@en
P2093
Jose L Nieva
Steve Bryson
P304
P3181
P356
10.1016/J.JMB.2008.09.024
P407
P577
2008-12-12T00:00:00Z