Structural Analysis of Spiro β-Lactone Proteasome Inhibitors - Wikidata - awgldk - TriplyDB

Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

http://www.wikidata.org/entity/Q27652533

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A Minimal β-Lactone Fragment for Selective β5c or β5i Proteasome Inhibitors α,β-Unsaturated carbonyl system of chalcone-based derivatives is responsible for broad inhibition of proteasomal activity and preferential killing of human papilloma virus (HPV) positive cervical cancer cells.Fundamental reaction pathway and free energy profile of proteasome inhibition by syringolin A (SylA).Fundamental reaction pathway for peptide metabolism by proteasome: insights from first-principles quantum mechanical/molecular mechanical free energy calculations Natural products and their biological targets: proteomic and metabolomic labeling strategies.Exploiting nature's rich source of proteasome inhibitors as starting points in drug development.Synthesis and pharmacology of proteasome inhibitors.Boron-Based Drug Design.Fundamental reaction pathway and free energy profile for inhibition of proteasome by Epoxomicin.Palladium-catalyzed cascade annulation to construct functionalized β- and γ-lactones in ionic liquids.Synthesis and biological activity of simplified belactosin C analogues.

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P2860

Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

http://www.wikidata.org/entity/Q27652533

description

2008 nî lūn-bûn

@nan

2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

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Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

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Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

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Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

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Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

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Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

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Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

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Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

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Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

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Journal of the American Chemical Society

P1476

Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

@en

P2093

Emily P Balskus

http://www.w3.org/2001/XMLSchema#string

Eric N Jacobsen

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P2860

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution

Structure of 20S proteasome from yeast at 2.4 A resolution

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.

Proteasome inhibitors: from research tools to drug candidates.

Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.

Inhibitor-binding mode of homobelactosin C to proteasomes: new insights into class I MHC ligand generation.

Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach.

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14981-3

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scholarly article

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10.1021/JA806059T

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45

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130

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2008-11-12T00:00:00Z

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244443752

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18928262

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2587002

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