Structure of ( E )-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate Pathway - Wikidata - awgldk - TriplyDB

Structure of ( E )-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate Pathway

Structure of ( E )-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate Pathway

http://www.wikidata.org/entity/Q27652996

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Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme Probing the reaction mechanism of IspH protein by x-ray structure analysis Discovery of acetylene hydratase activity of the iron–sulphur protein IspH Structures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe4S4] Protein IspH Are Free Radicals Involved in IspH Catalysis? An EPR and Crystallographic Investigation Insights into the Binding of Pyridines to the Iron–Sulfur Enzyme IspH Structure of the (E)-4-hydroxy-3-methyl-but-2-enyl-diphosphate reductase from Plasmodium falciparum The suf iron-sulfur cluster synthesis pathway is required for apicoplast maintenance in malaria parasites New Insight into Isoprenoids Biosynthesis Process and Future Prospects for Drug Designing in Plasmodium Utilizing a dynamical description of IspH to aid in the development of novel antimicrobial drugs Bioorganometallic mechanism of action, and inhibition, of IspH Isoprenoid Biosynthesis in Pathogenic Bacteria: Nuclear Resonance Vibrational Spectroscopy Provides Insight into the Unusual [4Fe-4S] Cluster of the E. coli LytB/IspH Protein.Bioorganometallic chemistry with IspG and IspH: structure, function, and inhibition of the [Fe(4)S(4)] proteins involved in isoprenoid biosynthesis.Use of Broken-Symmetry Density Functional Theory To Characterize the IspH Oxidized State: Implications for IspH Mechanism and Inhibition.Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): a HYSCORE Investigation N-Terminal Region of GbIspH1, Ginkgo biloba IspH Type 1, May Be Involved in the pH-Dependent Regulation of Enzyme Activity Study of IspH, a key enzyme in the methylerythritol phosphate pathway using fluoro-substituted substrate analogues LytB1 and LytB2 of Mycobacterium tuberculosis Are Not Genetically Redundant A closer look at the spectroscopic properties of possible reaction intermediates in wild-type and mutant (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase.Mechanistic studies of an IspH-catalyzed reaction: implications for substrate binding and protonation in the biosynthesis of isoprenoids.IspH-RPS1 and IspH-UbiA: "Rosetta Stone" Proteins.Biosynthesis of isoprene units: Mössbauer spectroscopy of substrate and inhibitor binding to the [4Fe-4S] cluster of the LytB/IspH enzyme.Inhibition of IspH, a [4Fe-4S]2+ enzyme involved in the biosynthesis of isoprenoids via the methylerythritol phosphate pathway.Structure and Function of Four Classes of the 4Fe-4S Protein, IspH.Terpene biosynthesis: modularity rules Methylerythritol phosphate pathway of isoprenoid biosynthesis.Mechanistic aspects of carotenoid biosynthesis.Molecular cloning and functional identification of a cDNA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase from Tripterygium wilfordii.Radical S-adenosylmethionine enzymes.Biochemistry of the non-mevalonate isoprenoid pathway.Isoprenoids in three-dimensional space: the stereochemistry of terpene biosynthesis.Transition metal-promoted biomimetic steps in total syntheses.An in silico structural insights into Plasmodium LytB protein and its inhibition.Targeting isoprenoid biosynthesis for drug discovery: bench to bedside Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms.Mechanistic insights into the reductive dehydroxylation pathway for the biosynthesis of isoprenoids promoted by the IspH enzyme.The amino-terminal conserved domain of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase is critical for its function in oxygen-evolving photosynthetic organisms.Two unexpected promiscuous activities of the iron-sulfur protein IspH in production of isoprene and isoamylene.Inhibition of the 4Fe-4S Proteins IspG and IspH: an EPR, ENDOR and HYSCORE Investigation.An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis.

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Structure of ( E )-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate Pathway

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2008 nî lūn-bûn

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2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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Structure of ( E )-4-Hydroxy-3 ...... of the Non-Mevalonate Pathway

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Structure of ( E )-4-Hydroxy-3 ...... of the Non-Mevalonate Pathway

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Structure of ( E )-4-Hydroxy-3 ...... of the Non-Mevalonate Pathway

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Structure of ( E )-4-Hydroxy-3 ...... of the Non-Mevalonate Pathway

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Structure of ( E )-4-Hydroxy-3 ...... of the Non-Mevalonate Pathway

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Journal of the American Chemical Society

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Structure of ( E )-4-Hydroxy-3 ...... of the Non-Mevalonate Pathway

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Ingo Rekittke

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Jochen Wiesner

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Joo Hwan No

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Kathrin Troschke

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Weiya Xu

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The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

JPred: a consensus secondary structure prediction server

Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein.

Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase.

Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein.

Terpenoid biosynthesis from 1-deoxy-D-xylulose in higher plants by intramolecular skeletal rearrangement.

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10.1021/JA806668Q

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