Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors † , ‡ - Wikidata - awgldk - TriplyDB

Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors † , ‡

Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors † , ‡

http://www.wikidata.org/entity/Q27653042

about

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle HDAC8 substrates: Histones and beyond Small molecule inhibitors of zinc-dependent histone deacetylases Structures of Metal-Substituted Human Histone Deacetylase 8 Provide Mechanistic Inferences on Biological Function,Structural Basis of the Antiproliferative Activity of Largazole, a Depsipeptide Inhibitor of the Histone Deacetylases Structure of HDAC3 bound to co-repressor and inositol tetraphosphate Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders Structural insights into HDAC6 tubulin deacetylation and its selective inhibition Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance.Activation and inhibition of histone deacetylase 8 by monovalent cations.Histone deacetylase 10 structure and molecular function as a polyamine deacetylase.Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme Variable active site loop conformations accommodate the binding of macrocyclic largazole analogues to HDAC8 Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes.On the inhibition of histone deacetylase 8 Metabolism as a key to histone deacetylase inhibition.Dynamic structure-based pharmacophore model development: a new and effective addition in the histone deacetylase 8 (HDAC8) inhibitor discovery.An enzyme-coupled assay measuring acetate production for profiling histone deacetylase specificity.On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis KDAC8 with High Basal Velocity Is Not Activated by N-Acetylthioureas.Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase.Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8.Biochemical and structural characterization of HDAC8 mutants associated with Cornelia de Lange syndrome spectrum disorders Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.General Base-General Acid Catalysis in Human Histone Deacetylase 8.Insights from comprehensive multiple receptor docking to HDAC8.Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors--What Some May Have Forgotten or Would Rather Forget?Energetically unfavorable amide conformations for N6-acetyllysine side chains in refined protein structures.Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity.Discovery and mechanism of natural products as modulators of histone acetylation.Binding ensemble profiling with photoaffinity labeling (BEProFL) approach: mapping the binding poses of HDAC8 inhibitors Recent advances in the development of polyamine analogues as antitumor agents.Loop interactions and dynamics tune the enzymatic activity of the human histone deacetylase 8.Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8.Purification of metal-dependent lysine deacetylases with consistently high activity.Lysine Deacetylases Exhibit Distinct Changes in Activity Profiles Due to Fluorophore Conjugation of Substrates.Structural aspects of HDAC8 mechanism and dysfunction in Cornelia de Lange syndrome spectrum disorders.HDACs and HDAC Inhibitors in Cancer Development and Therapy.

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Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors † , ‡

http://www.wikidata.org/entity/Q27653042

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2008 nî lūn-bûn

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2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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Structural Studies of Human Hi ...... Substrate and Inhibitors † , ‡

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Structural Studies of Human Hi ...... Substrate and Inhibitors † , ‡

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Structural Studies of Human Hi ...... Substrate and Inhibitors † , ‡

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Carol A Fierke

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David W Christianson

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Samuel G Gattis

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Stephanie L Gantt

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P2860

Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor

Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain

Histone deacetylases (HDACs): characterization of the classical HDAC family

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

Evolution of the arginase fold and functional diversity

Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation

Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

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10.1021/BI801610C

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51

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47

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Daniel P Dowling

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23568226

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19053282

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2635894

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