Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins
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Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerizationThe individual N- and C-lobes of calmodulin tether to the Cav1.2 channel and rescue the channel activity from run-down in ventricular myocytes of guinea-pig heartThe Ca(2+)-dependent interaction of calpastatin domain L with the C-terminal tail of the Cav1.2 channelCalmodulin regulation (calmodulation) of voltage-gated calcium channelsL-type calcium channel targeting and local signalling in cardiac myocytesTowards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium ChannelsDeterminants in CaV1 Channels That Regulate the Ca2+ Sensitivity of Bound CalmodulinAllosteric mechanism of water-channel gating by Ca2+–calmodulinThe TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding propertiesMolecular mechanisms of calmodulin action on TRPV5 and modulation by parathyroid hormoneGraded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channelsEffect of Ca(v)beta subunits on structural organization of Ca(v)1.2 calcium channels.Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation.Natural inequalities: why some L-type Ca2+ channels work harder than othersStructural insights into activation of the retinal L-type Ca²⁺ channel (Cav1.4) by Ca²⁺-binding protein 4 (CaBP4)Mechanism of μ-conotoxin PIIIA binding to the voltage-gated Na+ channel NaV1.4.Calmodulin overexpression does not alter Cav1.2 function or oligomerization state.Calpastatin domain L is a partial agonist of the calmodulin-binding site for channel activation in Cav1.2 Ca2+ channels.Ca2+ signaling amplification by oligomerization of L-type Cav1.2 channels.Structural insights into neuronal K+ channel-calmodulin complexes.Atomic resolution experimental phase information reveals extensive disorder and bound 2-methyl-2,4-pentanediol in Ca(2+)-calmodulinPost-transcriptional modifications and "Calmodulation" of voltage-gated calcium channel function: Reflections by two collaborators of David T YueConformational heterogeneity of the calmodulin binding interface.Lessons from high-throughput protein crystallization screening: 10 years of practical experience.Competitive and non-competitive regulation of calcium-dependent inactivation in CaV1.2 L-type Ca2+ channels by calmodulin and Ca2+-binding protein 1Ca(2+) entry into neurons is facilitated by cooperative gating of clustered CaV1.3 channels.What can naturally occurring mutations tell us about Ca(v)1.x channel function?Apo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain.L-type calcium channel auto-regulation of transcription.Trafficking and stability of voltage-gated calcium channels.L-type Ca2+ channel function during Timothy syndromeSeeing the forest through the trees: towards a unified view on physiological calcium regulation of voltage-gated sodium channels.Structural diversity of calmodulin binding to its target sites.Structural analysis of calmodulin binding to ion channels demonstrates the role of its plasticity in regulation.The many structural faces of calmodulin: a multitasking molecular jackknife.NMR studies of the interaction of calmodulin with IQ motif peptides.Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome.Multiple Calmodulin-Binding Sites Positively and Negatively Regulate Arabidopsis CYCLIC NUCLEOTIDE-GATED CHANNEL12.A double tyrosine motif in the cardiac sodium channel domain III-IV linker couples calcium-dependent calmodulin binding to inactivation gatingApocalmodulin itself promotes ion channel opening and Ca(2+) regulation.
P2860
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P2860
Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Crystal structure of dimeric c ...... s bridged by Ca2+* calmodulins
@ast
Crystal structure of dimeric c ...... s bridged by Ca2+* calmodulins
@en
Crystal structure of dimeric c ...... by Ca2+{middle dot}calmodulins
@nl
type
label
Crystal structure of dimeric c ...... s bridged by Ca2+* calmodulins
@ast
Crystal structure of dimeric c ...... s bridged by Ca2+* calmodulins
@en
Crystal structure of dimeric c ...... by Ca2+{middle dot}calmodulins
@nl
prefLabel
Crystal structure of dimeric c ...... s bridged by Ca2+* calmodulins
@ast
Crystal structure of dimeric c ...... s bridged by Ca2+* calmodulins
@en
Crystal structure of dimeric c ...... by Ca2+{middle dot}calmodulins
@nl
P2093
P2860
P3181
P356
P1476
Crystal structure of dimeric c ...... s bridged by Ca2+* calmodulins
@en
P2093
Florante A Quiocho
Guojun Yang
Jennifer L Fallon
Liangwen Xiong
Mariah R Baker
Robert T Dirksen
Ryan E Loy
Susan L Hamilton
P2860
P304
P3181
P356
10.1073/PNAS.0807487106
P407
P577
2009-03-11T00:00:00Z