Characterization of the active site of S. aureus monofunctional glycosyltransferase (Mtg) by site-directed mutation and structural analysis of the protein complexed with moenomycin
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Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New AntibacterialsFunctional and Structural Analysis of a Key Region of the Cell Wall Inhibitor MoenomycinCrystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanismStructural basis for catalysis at the membrane-water interface.Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activityPrimer preactivation of peptidoglycan polymerases.Monofunctional transglycosylases are not essential for Staphylococcus aureus cell wall synthesis.Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activityTargeting Bacterial Cell Wall Peptidoglycan Synthesis by Inhibition of Glycosyltransferase Activity.Modular synthesis of diphospholipid oligosaccharide fragments of the bacterial cell wall and their use to study the mechanism of moenomycin and other antibiotics.Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitorsMoenomycin resistance mutations in Staphylococcus aureus reduce peptidoglycan chain length and cause aberrant cell division.The molecular biology of moenomycins: towards novel antibiotics based on inhibition of bacterial peptidoglycan glycosyltransferases.Peptidoglycan biosynthesis machinery: a rich source of drug targets.Peptidoglycan glycosyltransferase substrate mimics as templates for the design of new antibacterial drugs.Prospects for new antibiotics: a molecule-centered perspective.Bioactive oligosaccharide natural products.Prospects for novel inhibitors of peptidoglycan transglycosylasesStructural Insights into Inhibition of Escherichia coli Penicillin-binding Protein 1B.The role of the substrate lipid in processive glycan polymerization by the peptidoglycan glycosyltransferases.Complete characterization of the seventeen step moenomycin biosynthetic pathway.Envelope Structures of Gram-Positive Bacteria.Optimization of conditions for the glycosyltransferase activity of penicillin-binding protein 1a from Thermotoga maritima.Effect of the Peptide Moiety of Lipid II on Bacterial Transglycosylase
P2860
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P2860
Characterization of the active site of S. aureus monofunctional glycosyltransferase (Mtg) by site-directed mutation and structural analysis of the protein complexed with moenomycin
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Characterization of the active ...... tein complexed with moenomycin
@ast
Characterization of the active ...... tein complexed with moenomycin
@en
Characterization of the active ...... tein complexed with moenomycin
@nl
type
label
Characterization of the active ...... tein complexed with moenomycin
@ast
Characterization of the active ...... tein complexed with moenomycin
@en
Characterization of the active ...... tein complexed with moenomycin
@nl
prefLabel
Characterization of the active ...... tein complexed with moenomycin
@ast
Characterization of the active ...... tein complexed with moenomycin
@en
Characterization of the active ...... tein complexed with moenomycin
@nl
P2093
P1476
Characterization of the active ...... tein complexed with moenomycin
@en
P2093
Alita A Miller
Anil Mistry
Bailin Shaw
Holly Heaslet
P304
P356
10.1016/J.JSB.2009.04.010
P577
2009-08-01T00:00:00Z