Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multifunctional NAD Hydrolase
about
Molecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolaseMechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single CrystalCD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose TemplateStructural and biochemical characterization of NarE, an iron-containing ADP-ribosyltransferase from Neisseria meningitidisCytosolic CD38 protein forms intact disulfides and is active in elevating intracellular cyclic ADP-riboseDesign, synthesis and biological characterization of novel inhibitors of CD38.CD38 and chronic lymphocytic leukemia: a decade later.NAD+-metabolizing ecto-enzymes shape tumor-host interactions: the chronic lymphocytic leukemia model.Roles of cADPR and NAADP in pancreatic cells.Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization.Aberrant cyclization affords a C-6 modified cyclic adenosine 5'-diphosphoribose analogue with biological activity in Jurkat T cells.Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid "L-cyclic inosine 5'-diphosphate ribose".Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase.The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging.
P2860
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P2860
Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multifunctional NAD Hydrolase
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural Basis for Enzymatic ...... Multifunctional NAD Hydrolase
@ast
Structural Basis for Enzymatic ...... Multifunctional NAD Hydrolase
@en
Structural Basis for Enzymatic ...... Multifunctional NAD Hydrolase
@nl
type
label
Structural Basis for Enzymatic ...... Multifunctional NAD Hydrolase
@ast
Structural Basis for Enzymatic ...... Multifunctional NAD Hydrolase
@en
Structural Basis for Enzymatic ...... Multifunctional NAD Hydrolase
@nl
prefLabel
Structural Basis for Enzymatic ...... Multifunctional NAD Hydrolase
@ast
Structural Basis for Enzymatic ...... Multifunctional NAD Hydrolase
@en
Structural Basis for Enzymatic ...... Multifunctional NAD Hydrolase
@nl
P2093
P2860
P356
P1476
Structural basis for enzymatic ...... multifunctional NAD hydrolase
@en
P2093
Barry V L Potter
Hening Lin
Hon Cheung Lee
Hong Jiang
Irina A Kriksunov
Norman Oppenheimer
Richard Graeff
P2860
P304
27637-27645
P356
10.1074/JBC.M109.031005
P407
P50
P577
2009-07-28T00:00:00Z