Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model

Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model

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http://www.wikidata.org/entity/Q27656970
Substrate binding process and mechanistic functioning of type 1 11β-hydroxysteroid dehydrogenase from enhanced sampling methods.Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases.11β-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus.11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors still improve metabolic phenotype in male 11β-HSD1 knockout mice suggesting off-target mechanisms.Continuous inhibition of 11β-hydroxysteroid dehydrogenase type I in adipose tissue leads to tachyphylaxis in humans and rats but not in mice.Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors.11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action.Crystal structures of 11β-hydroxysteroid dehydrogenase type 1 and their use in drug discovery.New perspectives on the development of antiobesity drugs.Mouse 11β-hydroxysteroid dehydrogenase type 2 for human application: homology modeling, structural analysis and ligand-receptor interaction.Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.Glucose-dependent insulinotropic polypeptide reduces fat-specific expression and activity of 11β-hydroxysteroid dehydrogenase type 1 and inhibits release of free fatty acids.On-column ligand exchange for structure-based drug design: a case study with human 11β-hydroxysteroid dehydrogenase type 1.Metabolism-guided drug designProtein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids from Boswellia Oleo-Gum Resins
P2860

Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model

Item
http://www.wikidata.org/entity/Q27656970
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Efficacious 11beta-hydroxyster ...... et-induced obesity mouse model
@ast
Efficacious 11beta-hydroxyster ...... et-induced obesity mouse model
@en
Efficacious 11beta-hydroxyster ...... et-induced obesity mouse model
@nl
type
label
Efficacious 11beta-hydroxyster ...... et-induced obesity mouse model
@ast
Efficacious 11beta-hydroxyster ...... et-induced obesity mouse model
@en
Efficacious 11beta-hydroxyster ...... et-induced obesity mouse model
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prefLabel
Efficacious 11beta-hydroxyster ...... et-induced obesity mouse model
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Efficacious 11beta-hydroxyster ...... et-induced obesity mouse model
@en
Efficacious 11beta-hydroxyster ...... et-induced obesity mouse model
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P921
P356
P1433
P1476
Efficacious 11beta-hydroxyster ...... et-induced obesity mouse model
@en
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P921