Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition

Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition

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http://www.wikidata.org/entity/Q27656985
Enzyme Inhibition by Hydroamination: Design and Mechanism of a Hybrid Carmaphycin-Syringolin Enone Proteasome InhibitorSynthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitorsGenerating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamidesDiscovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors.Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.Oxadiazole-isopropylamides as potent and noncovalent proteasome inhibitors.Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogsExploiting nature's rich source of proteasome inhibitors as starting points in drug development.Recent advances in fluorination techniques and their anticipated impact on drug metabolism and toxicity.Curcumin analogues with potent and selective anti-proliferative activity on acute promyelocytic leukemia: involvement of accumulated misfolded nuclear receptor co-repressor (N-CoR) protein as a basis for selective activity.Fundamental reaction pathway and free energy profile for inhibition of proteasome by Epoxomicin.Bioinspired total synthesis and human proteasome inhibitory activity of (-)-salinosporamide A, (-)-homosalinosporamide A, and derivatives obtained via organonucleophile promoted bis-cyclizations.(S)-4-Trimethylsilyl-3-butyn-2-ol as an auxiliary for stereocontrolled synthesis of salinosporamide analogs with modifications at positions C2 and C5.A(1,3)-strain enabled retention of chirality during bis-cyclization of beta-ketoamides: total synthesis of (-)-salinosporamide A and (-)-homosalinosporamide A.Tunable Probes with Direct Fluorescence Signals for the Constitutive and Immunoproteasome.
P2860

Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition

Item
http://www.wikidata.org/entity/Q27656985
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Snapshots of the fluorosalinos ...... e tuning proteasome inhibition
@ast
Snapshots of the fluorosalinos ...... e tuning proteasome inhibition
@en
Snapshots of the fluorosalinos ...... e tuning proteasome inhibition
@nl
type
label
Snapshots of the fluorosalinos ...... e tuning proteasome inhibition
@ast
Snapshots of the fluorosalinos ...... e tuning proteasome inhibition
@en
Snapshots of the fluorosalinos ...... e tuning proteasome inhibition
@nl
prefLabel
Snapshots of the fluorosalinos ...... e tuning proteasome inhibition
@ast
Snapshots of the fluorosalinos ...... e tuning proteasome inhibition
@en
Snapshots of the fluorosalinos ...... e tuning proteasome inhibition
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
Snapshots of the fluorosalinos ...... e tuning proteasome inhibition
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698