Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor - Wikidata - awgldk - TriplyDB

Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

http://www.wikidata.org/entity/Q27657391

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Eosinophilia Associated with Disorders of Immune Deficiency or Immune Dysregulation Regulation of small GTPases by GEFs, GAPs, and GDIs Approaches of targeting Rho GTPases in cancer drug discovery Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease Structural Basis of Membrane Targeting by the Dock180 Family of Rho Family Guanine Exchange Factors (Rho-GEFs)Structure of Shigella IpgB2 in Complex with Human RhoA: IMPLICATIONS FOR THE MECHANISM OF BACTERIAL GUANINE NUCLEOTIDE EXCHANGE FACTOR MIMICRY Structural basis of Fic-mediated adenylylation GDP-bound and Nucleotide-free Intermediates of the Guanine Nucleotide Exchange in the Rab5{middle dot}Vps9 System Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (DOCK) Nucleotide Exchange Factors Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB Direct metal recognition by guanine nucleotide-exchange factor in the initial step of the exchange reaction Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndrome R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases The RhoGEF DOCK10 is essential for dendritic spine morphogenesis ELMO recruits actin cross-linking family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome.The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family Dedicator of cytokinesis 8 (DOCK8) deficiency Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells.Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration.A minimal Rac activation domain in the unconventional guanine nucleotide exchange factor Dock180.SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC.Fine-Tuning of the Actin Cytoskeleton and Cell Adhesion During Drosophila Development by the Unconventional Guanine Nucleotide Exchange Factors Myoblast City and Sponge.Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts.Coevolution of RAC Small GTPases and their Regulators GEF Proteins.Nucleotide release sequences in the protein kinase SRPK1 accelerate substrate phosphorylation.Prenylation and membrane localization of Cdc42 are essential for activation by DOCK7.Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity.How Bacteria Subvert Animal Cell Structure and Function.Rho-guanine nucleotide exchange factors during development: Force is nothing without control.Severe combined immunodeficiences: new and old scenarios.Severe combined immunodeficiency--an update.Ras GTPases' interaction with effector domains: Breaking the families' barrier.An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling.

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P2860

Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

http://www.wikidata.org/entity/Q27657391

description

2009 nî lūn-bûn

@nan

2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

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2009年論文

@zh-tw

2009年论文

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name

Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

@ast

Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

@en

Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

@nl

type

label

Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

@ast

Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

@en

Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

@nl

prefLabel

Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

@ast

Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

@en

Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

@nl

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SCIENCE.1174468

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Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

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P2093

Christopher J Marshall

http://www.w3.org/2001/XMLSchema#string

David Barford

http://www.w3.org/2001/XMLSchema#string

Jing Yang

http://www.w3.org/2001/XMLSchema#string

S Mark Roe

http://www.w3.org/2001/XMLSchema#string

P2860

Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP

CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration

Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.

An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling

DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells

The structural basis of the activation of Ras by Sos

A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling.

GEF what? Dock180 and related proteins help Rac to polarize cells in new ways

DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane

Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: Two different nucleotide states in one crystal

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1398-402

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scholarly article

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1583084

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10.1126/SCIENCE.1174468

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5946

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325

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2009-09-11T00:00:00Z

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26803416

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19745154

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