Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors
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Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for theEandZisomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductaseIdentification of distant drug off-targets by direct superposition of binding pocket surfacesDiscovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential.The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agentsStructure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase.Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.Enaminonitrile as Building Block in Heterocyclic Synthesis: Synthesis of Novel 4H-Furo[2,3-d][1,3]oxazin-4-one and Furo[2,3-d]pyrimidin-4(3H)-one Derivatives
P2860
Q27666132-4D64CFE2-1D18-4537-AC02-A0B026A9294BQ28538129-280E0F3F-4974-4EF9-904B-6FB84E136F6BQ33636107-07F2CF32-0661-4F8A-A041-33C855CCDD8EQ33872751-166BE1F0-256B-4224-94B5-1D9B61C3A6EBQ35705202-74EDD1BC-91FA-48BC-8AB0-2C94258D75F7Q38728583-8B798B8E-20D7-493D-8092-88163C787CDAQ59145892-BA7550EB-F8B9-4878-9359-3D1E2131050B
P2860
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Design, synthesis, and X-ray c ...... drofolate reductase inhibitors
@ast
Design, synthesis, and X-ray c ...... drofolate reductase inhibitors
@en
Design, synthesis, and X-ray c ...... drofolate reductase inhibitors
@nl
type
label
Design, synthesis, and X-ray c ...... drofolate reductase inhibitors
@ast
Design, synthesis, and X-ray c ...... drofolate reductase inhibitors
@en
Design, synthesis, and X-ray c ...... drofolate reductase inhibitors
@nl
prefLabel
Design, synthesis, and X-ray c ...... drofolate reductase inhibitors
@ast
Design, synthesis, and X-ray c ...... drofolate reductase inhibitors
@en
Design, synthesis, and X-ray c ...... drofolate reductase inhibitors
@nl
P2093
P2860
P1476
Design, synthesis, and X-ray c ...... drofolate reductase inhibitors
@en
P2093
Aleem Gangjee
Dixy W Green
Linda A Warnke
Michael Ihnat
Sherry F Queener
Vivian Cody
Yibin Zeng
P2860
P304
P356
10.1016/J.BMC.2009.08.044
P407
P577
2009-10-15T00:00:00Z