Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase
about
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEKStructural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domainThe molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediatorIRAK4 dimerization and trans-autophosphorylation are induced by Myddosome assemblyPhospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage responseA mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpointRare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening studyThe FHA domain determines Drosophila Chk2/Mnk localization to key mitotic structures and is essential for early embryonic DNA damage responses.Novel design strategy for checkpoint kinase 2 inhibitors using pharmacophore modeling, combinatorial fusion, and virtual screening.Current perspectives on CHEK2 mutations in breast cancer.Identification of two poorly prognosed ovarian carcinoma subtypes associated with CHEK2 germ-line mutation and non-CHEK2 somatic mutation gene signatures.Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers.The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.Low prevalence of CHEK2 gene mutations in multiethnic cohorts of breast cancer patients in Malaysia.Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex.Association of Germline CHEK2 Gene Variants with Risk and Prognosis of Non-Hodgkin LymphomaResponse to DNA damage of CHEK2 missense mutations in familial breast cancer.Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-κB activationAnalysis of conditions affecting auto-phosphorylation of human kinases during expression in bacteria.p-T68-CHEK2 dimerizesp-T68-CHEK2 autophosphorylates'AND' logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7.Patient survival and tumor characteristics associated with CHEK2:p.I157T - findings from the Breast Cancer Association ConsortiumHomozygous inactivation of CHEK2 is linked to a familial case of multiple primary lung cancer with accompanying cancers in other organs.Inner nuclear membrane protein Lem2 facilitates Rad3-mediated checkpoint signaling under replication stress induced by nucleotide depletion in fission yeastThe hunt for antimitotic agents: an overview of structure-based design strategies.Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.Inhibition of the checkpoint kinase Chk1 induces DNA damage and cell death in human Leukemia and Lymphoma cells.Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response.Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis PathwayRing finger protein 126 (RNF126) suppresses ionizing radiation-induced p53-binding protein 1 (53BP1) focus formation.Pine needle oil induces G2/M arrest of HepG2 cells by activating the ATM pathway.Detection of Germline Mutations in Patients with Epithelial Ovarian Cancer Using Multi-Gene Panels: Beyond BRCA1/2.A kinetic test characterizes kinase intramolecular and intermolecular autophosphorylation mechanisms.Whole-genome landscape of pancreatic neuroendocrine tumours.Frequency of pathogenic germline mutation in CHEK2, PALB2, MRE11, and RAD50 in patients at high risk for hereditary breast cancer.A novel recurrent CHEK2 Y390C mutation identified in high-risk Chinese breast cancer patients impairs its activity and is associated with increased breast cancer risk.A recurrent CHEK2 p.H371Y mutation is associated with breast cancer risk in Chinese women.
P2860
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P2860
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase
@ast
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase
@en
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase
@nl
type
label
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase
@ast
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase
@en
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase
@nl
prefLabel
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase
@ast
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase
@en
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase
@nl
P2093
P3181
P1433
P1476
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase
@en
P2093
Nabil H Chehab
Nikola P Pavletich
Zhenjian Cai
P304
P3181
P356
10.1016/J.MOLCEL.2009.09.007
P577
2009-09-24T00:00:00Z