Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading Enzyme
about
Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme.Ubiquitin is a novel substrate for human insulin-degrading enzymeAlzheimer's disease--a panorama glimpseIdentification of the allosteric regulatory site of insulysinConformational states and recognition of amyloidogenic peptides of human insulin-degrading enzymeImidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysisMolecular Basis of Substrate Recognition and Degradation by Human Presequence ProteaseSte24p Mediates Proteolysis of Both Isoprenylated and Non-prenylated Oligopeptides.Identification of disulfide bonds in protein proteolytic degradation products using de novo-protein unique sequence tags approachModulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification.Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activationInsulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response.Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis.Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.An Extended Polyanion Activation Surface in Insulin Degrading Enzyme.Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in miceAmylin structure-function relationships and receptor pharmacology: implications for amylin mimetic drug development.Crystal Structure and Function of PqqF Protein in the Pyrroloquinoline Quinone Biosynthetic Pathway.Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes MellitusThe known and missing links between Toxoplasma gondii and schizophrenia.The role of copper(II) in the aggregation of human amylin.Functional relevance of a novel SlyX motif in non-conventional secretion of insulin-degrading enzyme.Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes.Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner.The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme.Mechanisms of peptide hydrolysis by aspartyl and metalloproteases.Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease.Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitinResveratrol Sustains Insulin-Degrading Enzyme Activity toward Aβ42
P2860
Q24304041-2FFBEF86-7747-41AD-B265-CFCCDE1D4399Q24321299-135BF61E-2601-4C30-863A-D0ED802BDEE0Q27011749-03755D20-7B64-4920-B9DA-82EC1B25E108Q27335211-634AC109-6730-4FF7-9B05-6C0F79E331AAQ27679412-493DF9F4-0396-49CB-AC3D-C48A5D3C661BQ27683399-BD02D7CC-C289-482F-AB92-4C9A327E5B26Q27684349-4FE65603-0D1E-44B9-9E41-30E320767A23Q27935867-7ADE48C8-B7E7-49EE-B5BF-136EE170C0D1Q30390914-AB80E27F-999D-41F6-8143-348EB3230E4EQ33963030-F9C6136C-E25D-4E92-A140-6F03B3F8EE4DQ34450404-A081C635-6D6B-42E9-8504-B736C66526D0Q34575644-3FAB1903-9754-46D2-BBBA-6AB6A400FB2DQ34729947-3DEB697B-D7A3-4ECD-B931-C4EA0E9D756EQ35075464-F35EC7A1-1EA9-47F7-9559-70E3102F9B0CQ35164366-AD0B146E-2815-4BB3-8320-02387D5E3388Q35694742-1CA9D20E-6927-4781-B15A-57FD8CFFF24CQ35953055-BE450A0F-ED0E-42A7-8D86-4C6A81F27AFEQ36087916-96EDD5B0-968A-4395-B249-3A57C24F718FQ36941265-678FA920-AAF2-4F35-B750-AE6929204C19Q37117280-A52C146A-620B-40AE-B8B4-F7E70B78BD5EQ38664408-3D00B238-A64C-4338-9FD4-D8981A0D7F8DQ38797294-ADA80AD2-8372-4264-B08C-38041AADE9EAQ38969830-850994F2-8B40-4EC9-9AE4-837921DF631CQ41788885-70C21B3B-E450-4E5F-B1B1-2245D9460A8DQ41826610-3585E1E1-45B2-4F3A-AB4E-FFAC004DF24DQ42409261-118EF8DD-1BD0-49D2-B86C-411E73F1917CQ42706060-7FC91A43-0E54-4C1D-BB13-7E13DBA7956CQ51423259-250BB0BD-92F7-4864-A6D4-C9DCE8B4CBC0Q51608953-9E796A71-D087-422B-95A7-53FF6488A97EQ52622522-7098647B-8891-419F-BF86-6A9F42A950F0Q57956865-4DB00C67-2E1F-4E67-9DF5-25E2EC1E7460Q58581134-5032E3CF-0169-44C6-9A83-1E68C8B1393D
P2860
Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading Enzyme
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Molecular Basis for the Recogn ...... Human Insulin-Degrading Enzyme
@ast
Molecular Basis for the Recogn ...... Human Insulin-Degrading Enzyme
@en
Molecular Basis for the Recogn ...... Human Insulin-Degrading Enzyme
@nl
type
label
Molecular Basis for the Recogn ...... Human Insulin-Degrading Enzyme
@ast
Molecular Basis for the Recogn ...... Human Insulin-Degrading Enzyme
@en
Molecular Basis for the Recogn ...... Human Insulin-Degrading Enzyme
@nl
prefLabel
Molecular Basis for the Recogn ...... Human Insulin-Degrading Enzyme
@ast
Molecular Basis for the Recogn ...... Human Insulin-Degrading Enzyme
@en
Molecular Basis for the Recogn ...... Human Insulin-Degrading Enzyme
@nl
P2093
P2860
P1476
Molecular Basis for the Recogn ...... Human Insulin-Degrading Enzyme
@en
P2093
Alexander B Schilling
Marika Manolopoulou
P2860
P304
P356
10.1016/J.JMB.2009.10.072
P407
P50
P577
2010-01-15T00:00:00Z