Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors
about
Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulationsDiscovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ ReductionEvaluation of aminohydantoins as a novel class of antimalarial agents.BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseAlzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS).Developing β-secretase inhibitors for treatment of Alzheimer's disease.Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system.Evaluation of spiropiperidine hydantoins as a novel class of antimalarial agentsSmall-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).The chemistry and biology of organic guanidine derivatives.Advances in the identification of β-secretase inhibitors.The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors.Synthesis of substituted 2-aminoimidazoles via Pd-catalyzed alkyne carboamination reactions. Application to the synthesis of preclathridine natural products.Fragment Binding to β-Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening Approaches.Triazolyl tryptoline derivatives as β-secretase inhibitors.Concise and diversity-oriented route toward polysubstituted 2-aminoimidazole alkaloids and their analogues.Hydrogen Bond Directed Photocatalytic Hydrodefluorination: Overcoming Electronic Control.Microwave-assisted one-pot synthesis and anti-biofilm activity of 2-amino-1H-imidazole/triazole conjugates.Synthesis of amino heterocycle aspartyl protease inhibitors.A Versatile Approach to CF3 -Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors.Accessing the applicability of polarized protein-specific charge in linear interaction energy analysis.Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment.Results of Beta Secretase-Inhibitor Clinical Trials Support Amyloid Precursor Protein-Independent Generation of Beta Amyloid in Sporadic Alzheimer's Disease.
P2860
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P2860
Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Design and synthesis of 5,5'-d ...... a-secretase (BACE1) inhibitors
@ast
Design and synthesis of 5,5'-d ...... a-secretase (BACE1) inhibitors
@en
Design and synthesis of 5,5'-d ...... a-secretase (BACE1) inhibitors
@nl
type
label
Design and synthesis of 5,5'-d ...... a-secretase (BACE1) inhibitors
@ast
Design and synthesis of 5,5'-d ...... a-secretase (BACE1) inhibitors
@en
Design and synthesis of 5,5'-d ...... a-secretase (BACE1) inhibitors
@nl
prefLabel
Design and synthesis of 5,5'-d ...... a-secretase (BACE1) inhibitors
@ast
Design and synthesis of 5,5'-d ...... a-secretase (BACE1) inhibitors
@en
Design and synthesis of 5,5'-d ...... a-secretase (BACE1) inhibitors
@nl
P2093
P356
P1476
Design and synthesis of 5,5'-d ...... a-secretase (BACE1) inhibitors
@en
P2093
Albert J Robichaud
Andrea Olland
Erik Wagner
Iwan Gunawan
Jim Turner
Jonathan Bard
Kristi Fan
Menelas Pangalos
Michael S Malamas
P304
P356
10.1021/JM901414E
P407
P577
2010-02-11T00:00:00Z